Publications by authors named "Margit Macdougall"

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Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.
Peng Sun, Christina S Bartlett, Chao Zheng, Tammy Bigwarfe, Joshuaine M Grant, Margit MacDougall

J Pharmacol Exp Ther· September 2022

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VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis.
Sarah Low, Haixia Wu, Kavita Jerath, Annette Tibolla, Birgit Fogal, Margit MacDougall

MAbs· February 2021

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Non-neutralizing antibodies increase endogenous circulating Ang1 levels.
Chao Zheng, Joshuaine Toth, Tammy Bigwarfe, Margit MacDougall, Kavita Jerath

MAbs· June 2019

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Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Benjamin D Stevens, John Litchfield, Jeffrey A Pfefferkorn, Karen Atkinson, Christian Perreault, Margit MacDougall

Bioorg Med Chem Lett· December 2013

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The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Jeffrey A Pfefferkorn, Meihua Tu, Kevin J Filipski, Angel Guzman-Perez, Jianwei Bian, Margit MacDougall

Bioorg Med Chem Lett· December 2012

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Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Jeffrey A Pfefferkorn, Angel Guzman-Perez, John Litchfield, Robert Aiello, Judith L Treadway, Margit Macdougall

J Med Chem· February 2012

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Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei

BMC Genomics· June 2011

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Generation and characterization of a monoclonal IgG antibody to polyethylene glycol.
David A Wunderlich, Margit Macdougall, Diane V Mierz, Joshuaine G Toth, Thomas M Buckholz

Hybridoma (Larchmt)· June 2007

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PDE-10A inhibitors as insulin secretagogues.
Louis-David Cantin, Steven Magnuson, David Gunn, Nicole Barucci, Marina Breuhaus, Margit Macdougall

Bioorg Med Chem Lett· May 2007

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Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist.
Clark Q Pan, Joanne M Buxton, Stephanie L Yung, Irene Tom, Ling Yang, Margit MacDougall

J Biol Chem· May 2006

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Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide.
Stephanie L Yung, Fernando Dela Cruz, Sarah Hamren, Jian Zhu, Manami Tsutsumi, Margit MacDougall

J Biol Chem· March 2003

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Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists.
Gaetan H Ladouceur, James H Cook, Donald L Hertzog, J Howard Jones, Thomas Hundertmark, Margit L MacDougall

Bioorg Med Chem Lett· December 2002

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Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis.
Roger A Smith, Donald L Hertzog, Martin H Osterhout, Gaetan H Ladouceur, Mary Korpusik, Margit L MacDougall

Bioorg Med Chem Lett· May 2002

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Discovery of 5-hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists.
Gaetan H Ladouceur, James H Cook, Elizabeth M Doherty, William R Schoen, Margit L MacDougall

Bioorg Med Chem Lett· February 2002

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