Publications by authors named "Maria Amann"

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P329G-engager: a universal mix & match antibody-based adaptor platform for cancer immunotherapy.
Marlena Surowka, Diana Darowski, Idil Hutter-Karakoc, Christina Claus, Claudia Ferrara-Koller, Maria Amann

MAbs· December 2026

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Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies.
Idil Hutter-Karakoc, Eleni Maria Varypataki, Aparna Neelakandhan, Simone Lang, Vesna Kramar, Maria Amann

Oncoimmunology· December 2025

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IL15/IL15Ra complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to expand progenitor TCF1+ CD8 T cells.
Miles Piper, Chloe A Hodgson, Jacob Gadwa, Maureen Hoen, Michael W Knitz, Maria Amann

Mol Cancer Ther· September 2025

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IL-10 from tumoral B cells modulates the diffuse large B-cell lymphoma microenvironment and response to immunotherapy.
Marcos Garcia-Lacarte, Sara C Grijalba, Javier Melchor, Marién Pascual, Enrique Goñi, Maria Amann

Blood· June 2025

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Safety and Antitumor Activity of a Novel aCD25 Treg Depleter RG6292 as a Single Agent and in Combination with Atezolizumab in Patients with Solid Tumors.
Valentina Gambardella, Michael Ong, Maria E Rodriguez-Ruiz, Jean-Pascal Machiels, Miguel F Sanmamed, Maria Amann

Cancer Res Commun· March 2025

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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment.
Jacob Gadwa, Justin Yu, Miles Piper, Michael W Knitz, Laurel B Darragh, Maria Amann

J Immunother Cancer· January 2025

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Author Correction: Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.
Laurel B Darragh, Jacob Gadwa, Tiffany T Pham, Benjamin Van Court, Brooke Neupert, Maria Amann

Nat Commun· October 2024

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Optimizing Early Clinical Investigations in Cancer Immunotherapy: The Translational Journey of RG6292, a Novel, Selective Treg-Depleting Antibody.
Sara Belli, Maria Amann, Lucy Hutchinson, Laurène Pousse, Afsaneh Abdolzade-Bavil

Clin Pharmacol Ther· September 2024

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IL15/IL15Rα complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to induce expansion of progenitor TCF1+ CD8 T cells.
Miles Piper, Jacob Gadwa, Chloe Hodgson, Michael Knitz, Elliott Yee, Maria Amann

bioRxiv· September 2024

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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC.
Jacob Gadwa, Maria Amann, Thomas E Bickett, Michael W Knitz, Laurel B Darragh

Cell Rep Med· August 2023

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Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.
Miles Piper, Maureen Hoen, Laurel B Darragh, Michael W Knitz, Diemmy Nguyen, Maria Amann

Cancer Cell· May 2023

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CD25 targeting with the afucosylated human IgG1 antibody RG6292 eliminates regulatory T cells and CD25+ blasts in acute myeloid leukemia.
Laurène Pousse, Koorosh Korfi, Bruno C Medeiros, Marco Berrera, Nadine Kumpesa, Maria Amann

Front Oncol· May 2023

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Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma.
Marta Larrayoz, Maria J Garcia-Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jimenez, Maria Amann

Nat Med· March 2023

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Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.
Laurel B Darragh, Jacob Gadwa, Tiffany T Pham, Benjamin Van Court, Brooke Neupert, Maria Amann

Nat Commun· November 2022

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CD25-T-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity.
Isabelle Solomon, Maria Amann, Anne Goubier, Frederick Arce Vargas, Dimitrios Zervas

Nat Cancer· December 2020

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The PET-Tracer Zr-Df-IAB22M2C Enables Monitoring of Intratumoral CD8 T-cell Infiltrates in Tumor-Bearing Humanized Mice after T-cell Bispecific Antibody Treatment.
Christoph M Griessinger, Tove Olafsen, Alessandro Mascioni, Ziyue Karen Jiang, Charles Zamilpa, Maria Amann

Cancer Res· July 2020

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Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer.
Marta Trüb, Franziska Uhlenbrock, Christina Claus, Petra Herzig, Martin Thelen, Maria Amann

J Immunother Cancer· July 2020

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Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Christina Claus, Claudia Ferrara, Wei Xu, Johannes Sam, Sabine Lang, Maria Amann

Sci Transl Med· June 2019

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CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas.
Michael D Oberst, Stacy Fuhrmann, Kathy Mulgrew, Maria Amann, Lily Cheng

MAbs· September 2015

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Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release.
Maria Amann, Sandrine D'Argouges, Grit Lorenczewski, Klaus Brischwein, Roman Kischel

J Immunother· June 2009

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Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans.
Maria Amann, Matthias Friedrich, Petra Lutterbuese, Eva Vieser, Grit Lorenczewski

Cancer Immunol Immunother· January 2009

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Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3.
Maria Amann, Klaus Brischwein, Petra Lutterbuese, Larissa Parr, Laetitia Petersen

Cancer Res· January 2008

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