Publications by authors named "Maria Seifer"

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The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
François-René Alexandre, Eric Badaroux, John P Bilello, Stéphanie Bot, Tony Bouisset, Maria Seifer

Bioorg Med Chem Lett· September 2017

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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.
Jean-Laurent Paparin, Agnès Amador, Eric Badaroux, Stéphanie Bot, Catherine Caillet, Maria Seifer

Bioorg Med Chem Lett· June 2017

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Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Claire Pierra Rouvière, Agnès Amador, Eric Badaroux, Thierry Convard, Daniel Da Costa, Maria Seifer

Bioorg Med Chem Lett· September 2016

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Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.
Gwenaëlle Sizun, Claire Pierra, Jérôme Peyronnet, Eric Badaroux, Céline Rabeson, Maria Seifer

Future Med Chem· July 2016

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Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor.
Cyril Dousson, François-René Alexandre, Agnès Amador, Séverine Bonaric, Stéphanie Bot, Maria Seifer

J Med Chem· March 2016

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Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.
Christophe C Parsy, François-René Alexandre, Valérie Bidau, Florence Bonnaterre, Guillaume Brandt, Maria Seifer

Bioorg Med Chem Lett· November 2015

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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.
François-René Alexandre, Guillaume Brandt, Catherine Caillet, Dominique Chaves, Thierry Convard, Maria Seifer

Bioorg Med Chem Lett· September 2015

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Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Christophe Parsy, François-René Alexandre, Guillaume Brandt, Catherine Caillet, Sylvie Cappelle, Maria Seifer

Bioorg Med Chem Lett· September 2014

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Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase.
Christopher Chapron, Rebecca Glen, Massimiliano La Colla, Benjamin A Mayes, Joseph F McCarville, Maria Seifer

Bioorg Med Chem Lett· June 2014

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Synthesis and biological evaluation of aryl-phospho-indole as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.
François-René Alexandre, Agnès Amador, Stéphanie Bot, Catherine Caillet, Thierry Convard, Maria Seifer

J Med Chem· January 2011

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Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.
Maria Seifer, April Patty, Ilaria Serra, Bin Li, David N Standring

Antiviral Res· February 2009

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2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.
Samira Benzaria, Dorothée Bardiot, Tony Bouisset, Clément Counor, Céline Rabeson, Maria Seifer

Antivir Chem Chemother· May 2008

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