Publications by authors named "Marian Castro"

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SERAAK2 as a Serotonin Receptor Ligand: Structural and Pharmacological In Vitro and In Vivo Evaluation.
Agnieszka A Kaczor, Agata Zięba, Tadeusz Karcz, Michał K Jastrzębski, Katarzyna Szczepańska, Marián Castro

Molecules· December 2025

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Study protocol for a multimethod investigation of the development of social and nonsocial reward responsivity and depression in autistic adolescents: Reward and Depression in Autism (RDA).
Jessica M Schwartzman, Autumn Kujawa, Shafali S Jeste, Blythe A Corbett, Wenyi Xu, Marian A Castro

BMC Psychol· June 2025

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Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome.
Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro

Ann Clin Transl Neurol· May 2025

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Synthesis, Experimental and Computational Evaluation of SERAAK1 as a 5-HT Receptor Ligand.
Agata Zięba, Ewa Kędzierska, Michał K Jastrzębski, Tadeusz Karcz, Agnieszka Olejarz-Maciej, Marián Castro

Molecules· May 2025

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Biochemical changes precede affective and cognitive anomalies in aging adult C57BL/6J mice with a prior history of adolescent alcohol binge-drinking.
C Leonardo Jimenez Chavez, Gavin P Scheldrup, Lauren E Madory, Christopher J E Denning, Edward C Lee, Marian Castro

Addict Biol· December 2024

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Discovery and in vitro Evaluation of Novel Serotonin 5-HT Receptor Ligands Identified Through Virtual Screening.
Agata Zięba, Damian Bartuzi, Piotr Stępnicki, Dariusz Matosiuk, Tomasz M Wróbel, Marián Castro

ChemMedChem· July 2024

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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives.
Filipe Areias, Carla Correia, Ashly Rocha, Sofia Teixeira, Marián Castro

Molecules· May 2024

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Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation.
Piotr Stępnicki, Olga Wronikowska-Denysiuk, Agata Zięba, Katarzyna M Targowska-Duda, Agata Bartyzel, Marián Castro

J Enzyme Inhib Med Chem· December 2023

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Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons.
Maria G Otero, Shaughn Bell, Alexander H Laperle, George Lawless, Zachary Myers, Marian A Castro

Int J Mol Sci· September 2023

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A subchronic history of binge-drinking elicits mild, age- and sex-selective, affective, and cognitive anomalies in C57BL/6J mice.
C Leonardo Jimenez Chavez, Eliyana Van Doren, Gavin Scheldrup, Emely Rivera, Jose Torres-Gonzalez, Marian Castro

Front Behav Neurosci· August 2023

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Development and Characterization of Novel Selective, Non-Basic Dopamine D Receptor Antagonists for the Treatment of Schizophrenia.
Piotr Stępnicki, Sylwia Wośko, Agata Bartyzel, Agata Zięba, Damian Bartuzi, Marián Castro

Molecules· May 2023

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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.
Piotr Stępnicki, Katarzyna M Targowska-Duda, Antón L Martínez, Agata Zięba, Olga Wronikowska-Denysiuk, Marián Castro

Eur J Med Chem· April 2023

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Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety.
Magda Kondej, Tomasz M Wróbel, Katarzyna M Targowska-Duda, Antón Leandro Martínez, Oliwia Koszła, Marián Castro

ChemMedChem· August 2022

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In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1.
Oliwia Koszła, Przemysław Sołek, Ewa Kędzierska, Piotr Listos, Marián Castro

Neurochem Res· June 2022

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Allosteric modulation of dopamine D receptor in complex with G and G proteins: the effect of subtle structural and stereochemical ligand modifications.
Justyna Żuk, Damian Bartuzi, Andrea G Silva, Monika Pitucha, Oliwia Koszła, Marián Castro

Pharmacol Rep· April 2022

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Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties.
Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Marián Castro

Molecules· February 2022

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N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand.
Agnieszka A Kaczor, Katarzyna M Targowska-Duda, Piotr Stępnicki, Andrea G Silva, Oliwia Koszła, Marián Castro

Neurochem Int· June 2021

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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder.
Enza Lacivita, Mauro Niso, Margherita Mastromarino, Andrea Garcia Silva, Cibell Resch, Marián Castro

ACS Chem Neurosci· April 2021

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New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and In Vitro Pharmacological Evaluation.
Elisa Magli, Beatrice Severino, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Marián Castro

Med Chem· January 2021

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-(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1- benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic.
Agnieszka A Kaczor, Katarzyna M Targowska-Duda, Andrea G Silva, Magda Kondej, Grażyna Biała, Marián Castro

Biomolecules· February 2020

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1-(2'-Bromobenzyl)-6,7-dihydroxy--methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D Dopamine Receptors.
Andrea G Silva, Laura Vila, Patrice Marques, Laura Moreno, Mabel Loza, Marián Castro

J Nat Prod· January 2020

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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.
Magda Kondej, Tomasz M Wróbel, Andrea G Silva, Piotr Stępnicki, Oliwia Koszła, Marián Castro

Eur J Med Chem· October 2019

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2-Aryladenine derivatives as a potent scaffold for A, A and dual A/A adenosine receptor antagonists: Synthesis and structure-activity relationships.
Filipe Areias, Carla Correia, Ashly Rocha, José Brea, Marián Castro

Bioorg Med Chem· August 2019

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Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship.
Ana P Bettencourt, Marián Castro, João P Silva, Francisco Fernandes, Olga P Coutinho

Med Chem· June 2019

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New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure⁻Activity Relationship.
Ana Bettencourt, Marián Castro, João Silva, Francisco Fernandes, Olga Coutinho

Molecules· October 2018

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