Publications by authors named "Mario A Shields"

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Trametinib Potentiates Anti-PD-1 Efficacy in Tumors Established from Chemotherapy-Primed Pancreatic Cancer Cells.
Thao D Pham, Anastasia E Metropulos, Nida Mubin, Jeffrey H Becker, Dhavan Shah, Mario A Shields

Mol Cancer Ther· December 2024

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Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer.
Jeffrey H Becker, Anastasia E Metropulos, Christina Spaulding, Alejandra M Marinelarena, Mario A Shields

Cancer Res· November 2024

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BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3.
Mario A Shields, Anastasia E Metropulos, Christina Spaulding, Khulood A Alzahrani, Tomonori Hirose

Cell Mol Gastroenterol Hepatol· October 2024

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BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss.
Mario A Shields, Anastasia E Metropulos, Christina Spaulding, Tomonori Hirose, Shigeo Ohno

bioRxiv· September 2023

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Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity.
Thao Nd Pham, Christina Spaulding, Mario A Shields, Anastasia E Metropulos, Dhavan N Shah

JCI Insight· May 2022

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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin.
Mario A Shields, Christina Spaulding, Anastasia E Metropulos, Mahmoud G Khalafalla, Thao N D Pham

Cell Rep· March 2022

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Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies.
Thao N D Pham, Mario A Shields, Christina Spaulding, Daniel R Principe, Bo Li

Cancers (Basel)· January 2021

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A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis.
Nicole D Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A Shields

Nat Commun· August 2020

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Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1.
Thao N D Pham, Sophie Stempel, Mario A Shields, Christina Spaulding, Krishan Kumar

Int J Mol Sci· September 2019

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Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.
Kazumi Ebine, Krishan Kumar, Thao N Pham, Mario A Shields, Katharine A Collier

Sci Rep· September 2018

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Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
Jean Albrengues, Mario A Shields, David Ng, Chun Gwon Park, Alexandra Ambrico

Science· September 2018

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Snail cooperates with KrasG12D to promote pancreatic fibrosis.
Mario A Shields, Kazumi Ebine, Vaibhav Sahai, Krishan Kumar, Kulsumjehan Siddiqui

Mol Cancer Res· September 2013

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Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression.
Seth B Krantz, Mario A Shields, Surabhi Dangi-Garimella, Hidayatullah G Munshi, David J Bentrem

J Surg Res· March 2012

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Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.
Mario A Shields, Seth B Krantz, David J Bentrem, Surabhi Dangi-Garimella, Hidayatullah G Munshi

J Biol Chem· February 2012

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Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.
Mario A Shields, Surabhi Dangi-Garimella, Amanda J Redig, Hidayatullah G Munshi

Biochem J· January 2012

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Ethanol differentially regulates snail family of transcription factors and invasion of premalignant and malignant pancreatic ductal cells.
Sarah T Ward, Surabhi Dangi-Garimella, Mario A Shields, Brett A Collander, Mohammed A Q Siddiqui

J Cell Biochem· October 2011

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MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling.
Seth B Krantz, Mario A Shields, Surabhi Dangi-Garimella, Eric C Cheon, Morgan R Barron

Mol Cancer Res· October 2011

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Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
Mario A Shields, Surabhi Dangi-Garimella, Seth B Krantz, David J Bentrem, Hidayatullah G Munshi

J Biol Chem· March 2011

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Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.
Surabhi Dangi-Garimella, Seth B Krantz, Morgan R Barron, Mario A Shields, Michael J Heiferman

Cancer Res· February 2011

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Contribution of epithelial-mesenchymal transition to pancreatic cancer progression.
Seth B Krantz, Mario A Shields, Surabhi Dangi-Garimella, David J Bentrem, Hidayatullah G Munshi

Cancers (Basel)· December 2010

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Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells.
Efstratios Katsoulidis, Evangelos Mavrommatis, Jennifer Woodard, Mario A Shields, Antonella Sassano

J Biol Chem· December 2010

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Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes.
Surabhi Dangi-Garimella, Amanda J Redig, Mario A Shields, Mohammed A Siddiqui, Hidayatullah G Munshi

J Biol Chem· September 2010

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Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells.
Mathew J Joseph, Surabhi Dangi-Garimella, Mario A Shields, Michelle E Diamond, Limin Sun

J Cell Biochem· October 2009

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