Publications by authors named "Marion Macfarlane"

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Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.
Aristeidis P Sfakianos, Rebecca M Raven, Tom Smith, Xiao-Ming Sun, Thomas E Mulroney, Marion MacFarlane

Nat Commun· December 2025

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PAXX/Ku interaction is rate limiting for repair of double-strand DNA breaks requiring end processing.
Joanna Gluza, Joanna Machnik, Malgorzata Szatkiewicz, Andrew Craxton, Steven W Hardwick, Marion MacFarlane

J Biol Chem· August 2025

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TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axis.
Niall A Buckley, Andrew Craxton, Xiao-Ming Sun, Emanuele Panatta, Lucia Giraldez Pinon, Marion MacFarlane

Cell Death Dis· November 2024

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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Jonathan Mannion, Valentina Gifford, Benjamin Bellenie, Winnie Fernando, Laura Ramos Garcia, Marion MacFarlane

Immunity· July 2024

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An optimised patient-derived explant platform for breast cancer reflects clinical responses to chemotherapy and antibody-directed therapy.
Constantinos Demetriou, Naila Abid, Michael Butterworth, Larissa Lezina, Pavandeep Sandhu, Marion MacFarlane

Sci Rep· June 2024

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Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells.
Yakinthi Chrisochoidou, Rajat Roy, Pooyeh Farahmand, Guadalupe Gonzalez, Jennifer Doig, Marion MacFarlane

Cell Death Dis· November 2023

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Multi-element analysis of tyre rubber for metal tracers.
David P O'Loughlin, Molly J Haugen, Jason Day, Andrew S Brown, Emma C Braysher, Marion MacFarlane

Environ Int· August 2023

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The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors.
Rachel E Hardy, Injae Chung, Yizhou Yu, Samantha H Y Loh, Nobuhiro Morone, Marion MacFarlane

Biol Direct· August 2023

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Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Kristel Martinez Lagunas, Deniz Pinar Savcigil, Matea Zrilic, Carlos Carvajal Fraile, Andrew Craxton, Marion MacFarlane

Sci Adv· July 2023

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Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade.
Juan Carlos Yam-Puc, Zhaleh Hosseini, Emily C Horner, Pehuén Pereyra Gerber, Nonantzin Beristain-Covarrubias, Marion MacFarlane

Nat Commun· June 2023

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Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma.
Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L Raffo-Iraolagoitia, Geeshath Jayasekera, Marion MacFarlane

Front Toxicol· June 2023

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Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Marion MacFarlane

Cell Death Differ· May 2023

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Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells.
Tatyana Chernova, Stefano Grosso, Xiao-Ming Sun, Angela Rubio Tenor, Joaquin Zacarias Cabeza, Marion MacFarlane

Int J Mol Sci· October 2022

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Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma.
Georgina S F Anderson, Jose Ballester-Beltran, George Giotopoulos, Jose A Guerrero, Sylvanie Surget, Marion MacFarlane

Blood· April 2022

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Author Correction: Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Marion MacFarlane

Sci Rep· March 2022

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Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Christian T Hellwig, M Eugenia Delgado, Josip Skoko, Lydia Dyck, Carol Hanna, Marion MacFarlane

Cell Death Differ· January 2022

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Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Marion MacFarlane

Sci Rep· September 2021

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The pathogenesis of mesothelioma is driven by a dysregulated translatome.
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Marion MacFarlane

Nat Commun· August 2021

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Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.
Gareth J Miles, Ian Powley, Seid Mohammed, Lynne Howells, J Howard Pringle, Marion MacFarlane

Lab Invest· March 2021

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Development of a patient-derived explant model for prediction of drug responses in endometrial cancer.
Anna Collins, Gareth J Miles, Ian R Powley, Roger Hew, J Howard Pringle, Marion MacFarlane

Gynecol Oncol· February 2021

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Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate.
Joanna L Fox, Michelle A Hughes, Xin Meng, Nikola A Sarnowska, Ian R Powley, Marion MacFarlane

Nat Commun· February 2021

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Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients.
Giuditta Viticchié, Ian Powley, Constantinos Demetriou, James Cooper, Michael Butterworth, Marion MacFarlane

J Vis Exp· February 2021

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Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors.
Calum J Greenhalgh, Ellie Karekla, Gareth J Miles, Ian R Powley, Catia Costa, Marion MacFarlane

Anal Chem· July 2020

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Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Marion MacFarlane

Elife· May 2020

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Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.
Ian R Powley, Meeta Patel, Gareth Miles, Howard Pringle, Lynne Howells, Marion MacFarlane

Br J Cancer· March 2020

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