Publications by authors named "Mark A Graham"

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Modular synthesis of cyclic β-difluoroamines.
Natalie G Charlesworth, Dhanarajan Arunprasath, Mark A Graham, Stephen P Argent, Oleksandr P Datsenko

Chem Commun (Camb)· July 2024

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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
Richard A Ward, Mark J Anderton, Paul Bethel, Jason Breed, Calum Cook, Mark A Graham

J Med Chem· December 2019

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Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes.
James R Smith, Beatrice S L Collins, Matthew J Hesse, Mark A Graham, Eddie L Myers

J Am Chem Soc· July 2017

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Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
Richard A Ward, Paul Bethel, Calum Cook, Emma Davies, Judit E Debreczeni, Mark A Graham

J Med Chem· April 2017

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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
Robert H Bradbury, Rowena Callis, Gregory R Carr, Huawei Chen, Edwin Clark, Mark A Graham

J Med Chem· September 2016

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Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
Richard A Ward, Nicola Colclough, Mairi Challinor, Judit E Debreczeni, Kay Eckersley, Mark A Graham

J Med Chem· June 2015

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Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
Jason G Kettle, Peter Ballard, Catherine Bardelle, Mark Cockerill, Nicola Colclough, Mark A Graham

J Med Chem· March 2015

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Synthesis of functionalized cyanopyrazoles via magnesium bases.
Allan Dishington, J Lyman Feron, Kathryn Gill, Mark A Graham, Ian Hollingsworth

Org Lett· December 2014

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Novel and versatile synthesis of disubstituted 1,2-dihydro-1,2,4-triazol-3-ones.
Mark A Graham, Paul A Bethel, Jonathan Burgess, Gary Fairley, Steve C Glossop

Org Lett· December 2013

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Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
M Raymond V Finlay, David Buttar, Susan E Critchlow, Allan P Dishington, Shaun M Fillery, Mark A Graham

Bioorg Med Chem Lett· June 2012

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The importance of the N-H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines.
Rina Soni, Fung Kei Cheung, Guy C Clarkson, Jose E D Martins, Mark A Graham

Org Biomol Chem· May 2011

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Kinetic and structural studies on 'tethered' Ru(II) arene ketone reduction catalysts.
Fung Kei Kathy Cheung, Adam J Clarke, Guy J Clarkson, David J Fox, Mark A Graham

Dalton Trans· February 2010

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The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing.
Clifford D Jones, David M Andrews, Andrew J Barker, Kevin Blades, Paula Daunt, Mark A Graham

Bioorg Med Chem Lett· December 2008

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Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode.
M Raymond V Finlay, David G Acton, David M Andrews, Andrew J Barker, Michael Dennis, Mark A Graham

Bioorg Med Chem Lett· August 2008

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Design and campaign synthesis of pyridine-based histone deacetylase inhibitors.
David M Andrews, Keith M Gibson, Mark A Graham, Zbigniew S Matusiak, Craig A Roberts

Bioorg Med Chem Lett· April 2008

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An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones.
Fung K Cheung, Changxue Lin, Franco Minissi, Adriana Lorente Crivillé, Mark A Graham

Org Lett· October 2007

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Studies on the Lewis acid mediated cleavage of alpha-aminoacetals: synthesis of novel 1,2-aminoethers, and evidence for alpha-alkoxy aziridinium ion intermediates.
Mark A Graham, Alan H Wadsworth, Abdul Zahid, Christopher M Rayner

Org Biomol Chem· March 2003

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