Publications by authors named "Mark Appleby"

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CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction.
Aascha A D'Elia Nee Brown, Helen Kiriazis, Jason Bloom, Jonathan Noonan, Ian Hsu, Mark W Appleby

JACC Basic Transl Sci· November 2025

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Exploring a patient-specific in vitro pipeline for stratification and drug response prediction of microglia-based therapeutics.
Carla Cuní-López, Romal Stewart, Satomi Okano, Garry L Redlich, Mark W Appleby

Sci Rep· March 2025

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Safety and activity of anti-CD14 antibody IC14 (atibuclimab) in ALS: Experience with expanded access protocol.
Dario Gelevski, Grace Addy, Margot Rohrer, Caroline Cohen, Aimee Roderick, Mark Appleby

Muscle Nerve· May 2023

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Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis.
Robert D Henderson, Jan M Agosti, Pamela A McCombe, Kathryn Thorpe, Susan Heggie, Mark W Appleby

Medicine (Baltimore)· October 2021

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Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development.
Heon Park, Karen Staehling, Mark Tsang, Mark W Appleby, Mary E Brunkow

Immunity· May 2012

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Engineering of stable bispecific antibodies targeting IL-17A and IL-23.
Robert Mabry, Katherine E Lewis, Margaret Moore, Patricia A McKernan, Thomas R Bukowski, Mark W Appleby

Protein Eng Des Sel· March 2010

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Randall H Friedline, David S Brown, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Mark Appleby

J Exp Med· February 2009

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A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity.
Heon Park, Karen Staehling-Hampton, Mark W Appleby, Mary E Brunkow, Tania Habib

J Exp Med· November 2008

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Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.
Rolf E Kuestner, David W Taft, Aaron Haran, Cameron S Brandt, Ty Brender, Mark Appleby

J Immunol· October 2007

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A novel mutation in CD83 results in the development of a unique population of CD4+ T cells.
Leon F García-Martínez, Mark W Appleby, Karen Staehling-Hampton, Dawn M Andrews, Yuching Chen

J Immunol· September 2004

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.
David G Winkler, May Kung Sutherland, James C Geoghegan, Changpu Yu, Trenton Hayes, Mark Appleby

EMBO J· December 2003

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A forward-genetic approach for analysis of the immune system.
Mark W Appleby, Fred Ramsdell

Nat Rev Immunol· June 2003

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Pretreatment with intragraft verapamil prior to percutaneous coronary intervention of saphenous vein graft lesions: results of the randomized, controlled vasodilator prevention on no-reflow (VAPOR) trial.
Andrew D Michaels, Mark Appleby, Matthew H Otten, Kent Dauterman, Thomas A Ports

J Invasive Cardiol· June 2002

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Key developments in cardiovascular medicine.
Mark A Appleby, Alistair Hall

Practitioner· June 2002

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Importance of the TIMI frame count: implications for future trials.
Mark A Appleby, Andrew D Michaels, Michael Chen, C Gibson Michael

Curr Control Trials Cardiovasc Med· January 2000

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