Publications by authors named "Mark Cobbold"

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An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release.
Miguel Gaspar, Marina Natoli, Laure Castan, Sharif Rahmy, Martin Korade, Mark Cobbold

J Immunother Cancer· August 2025

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LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity.
Des C Jones, Lorraine Irving, Rebecca Dudley, Seraina Blümli, Marcin Wolny, Mark Cobbold

J Immunother Cancer· April 2025

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The differential immunological impact of photon vs proton radiation therapy in high-grade lymphopenia in patients with gastrointestinal tumors.
James M Heather, Daniel W Kim, Sean M Sepulveda, Emily E van Seventer, Madeleine G Fish, Mark Cobbold

Clin Exp Immunol· January 2025

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Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers.
Allison M Barrett, Zachary T Britton, Rosa A Carrasco, Shannon Breen, Maria A S Broggi, Mark Cobbold

Clin Cancer Res· December 2024

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Correction: Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.
Songfa Zhang, Chuan Yan, David G Millar, Qiqi Yang, James M Heather, Mark Cobbold

Cancer Res· May 2024

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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.
Elizabeth L Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo, Mark Cobbold

Nat Commun· February 2024

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Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer.
Peter Zanvit, Dewald van Dyk, Christine Fazenbaker, Kelly McGlinchey, Weichuan Luo, Mark Cobbold

J Clin Invest· November 2023

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Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information.
James M Heather, Matthew J Spindler, Marta Herrero Alonso, Yifang Ivana Shui, David G Millar, Mark Cobbold

Nucleic Acids Res· July 2022

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Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy.
Songfa Zhang, Chuan Yan, David G Millar, Qiqi Yang, James M Heather, Mark Cobbold

Cancer Res· March 2022

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Tumor Infiltrating Lymphocytes Target HLA-I Phosphopeptides Derived From Cancer Signaling in Colorectal Cancer.
Sarah A Penny, Jennifer G Abelin, Stacy A Malaker, Paisley T Myers, Abu Z Saeed, Mark Cobbold

Front Immunol· December 2021

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Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer.
Ayumi Hashimoto, Debashis Sarker, Vikash Reebye, Sheba Jarvis, Mikael H Sodergren, Mark Cobbold

Clin Cancer Res· November 2021

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Single-cell imaging of T cell immunotherapy responses in vivo.
Chuan Yan, Qiqi Yang, Songfa Zhang, David G Millar, Eric J Alpert, Mark Cobbold

J Exp Med· October 2021

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Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.
Shenlan Mao, Raghothama Chaerkady, Wen Yu, Gina D'Angelo, Andrew Garcia, Mark Cobbold

Mol Cancer Ther· March 2021

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Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Kohei Shigeta, Aya Matsui, Hiroto Kikuchi, Sebastian Klein, Emilie Mamessier, Mark Cobbold

J Immunother Cancer· November 2020

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MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma.
Victor H Engelhard, Rebecca C Obeng, Kara L Cummings, Gina R Petroni, Angela L Ambakhutwala, Mark Cobbold

J Immunother Cancer· May 2020

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Massively parallel interrogation and mining of natively paired human TCRαβ repertoires.
Matthew J Spindler, Ayla L Nelson, Ellen K Wagner, Natasha Oppermans, John S Bridgeman, Mark Cobbold

Nat Biotechnol· May 2020

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Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma.
Kohei Shigeta, Meenal Datta, Tai Hato, Shuji Kitahara, Ivy X Chen, Mark Cobbold

Hepatology· April 2020

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Gastrointestinal manifestations in common variable immunodeficiency (CVID) are associated with an altered immunophenotype including B- and T-cell dysregulation.
Sara Barmettler, Mei-Sing Ong, Jocelyn R Farmer, Nancy Yang, Mark Cobbold

J Allergy Clin Immunol Pract· April 2020

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Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
David G Millar, Rakesh R Ramjiawan, Kosuke Kawaguchi, Nisha Gupta, Jiang Chen, Mark Cobbold

Nat Biotechnol· April 2020

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Murine xenograft bioreactors for human immunopeptidome discovery.
James M Heather, Paisley T Myers, Feng Shi, Mohammad Ovais Aziz-Zanjani, Keira E Mahoney, Mark Cobbold

Sci Rep· December 2019

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Aberrant X chromosome skewing and acquired clonal hematopoiesis in adult-onset common variable immunodeficiency.
Gabriel K Wong, Sara Barmettler, James M Heather, David Millar, Sarah A Penny, Mark Cobbold

JCI Insight· July 2019

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Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Clemens Grassberger, Theodore S Hong, Tai Hato, Beow Y Yeap, Jennifer Y Wo, Mark Cobbold

Int J Radiat Oncol Biol Phys· August 2018

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Can smart nanomedicine deliver effective targeted cytotoxic treatments to hepatocellular carcinomas while reducing the liver damage?
Shuichi Aoki, Mark Cobbold, Andrew X Zhu, Dan G Duda

Hepatology· March 2018

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The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Fiyaz Mohammed, Daniel H Stones, Angela L Zarling, Carrie R Willcox, Jeffrey Shabanowitz, Mark Cobbold

Oncotarget· August 2017

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Immune dysregulation in immunodeficiency disorders: The role of T-cell receptor sequencing.
Gabriel K Wong, James M Heather, Sara Barmettler, Mark Cobbold

J Autoimmun· June 2017

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