Publications by authors named "Mark Denison"

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Novel tricycle expanded purine nucleosides with pan-viral activity.
Céline Martin-Ghoteimi, Kyle A Davis, Rayane Ghoteimi, Meareg Amare, Meghan V Diefenbacher, Mark Denison

Bioorg Med Chem· December 2025

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Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.
Hery W Lee, Egor P Tchesnokov, Laura J Stevens, Tia M Hughes, Meghan V Diefenbacher, Mark R Denison

NAR Mol Med· July 2025

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The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.
Samantha L Grimes, Brook E Heaton, Mackenzie L Anderson, Katie Burke, Laura Stevens, Mark R Denison

J Virol· February 2025

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MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies.
Olubukola M Abiona, Nianshuang Wang, Sarah R Leist, Alexandra Schäfer, Adam S Cockrell, Mark R Denison

iScience· February 2025

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An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.
Nian E Zhou, Su Tang, Xuelin Bian, Maloy K Parai, Inna V Krieger, Mark R Denison

Cell Rep· November 2024

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The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.
Samantha L Grimes, Brook E Heaton, Mackenzie L Anderson, Katie Burke, Laura Stevens, Mark R Denison

bioRxiv· September 2024

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The Coronavirus helicase in replication.
Samantha L Grimes, Mark R Denison

Virus Res· August 2024

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Human Rotaviruses of Multiple Genotypes Acquire Conserved VP4 Mutations during Serial Passage.
Maximilian H Carter, Jennifer Gribble, Julia R Diller, Mark R Denison, Sara A Mirza

Viruses· June 2024

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Evaluation of antiviral activity of SARS-CoV-2 M inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.
Xiao Tong, Walter Keung, Lee D Arnold, Laura J Stevens, Andrea J Pruijssers, Mark Denison

Antimicrob Agents Chemother· November 2023

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A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance.
Samantha L Grimes, Young J Choi, Anoosha Banerjee, Gabriel Small, Jordan Anderson-Daniels, Mark R Denison

mBio· August 2023

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Positive-strand RNA viruses-a Keystone Symposia report.
Jennifer Cable, Mark R Denison, Margaret Kielian, William T Jackson, Ralf Bartenschlager

Ann N Y Acad Sci· March 2023

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Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.
Wesley H Self, Allison P Wheeler, Thomas G Stewart, Harry Schrager, Jason Mallada, Mark R Denison

Chest· November 2022

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Laura J Stevens, Andrea J Pruijssers, Hery W Lee, Calvin J Gordon, Egor P Tchesnokov, Mark R Denison

Sci Transl Med· August 2022

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Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness.
Jordan Anderson-Daniels, Jennifer Gribble, Mark Denison

J Virol· August 2022

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Integrating SARS-CoV-2 Antibody Results in Children Into Pandemic Response.
Andrea T Cruz, Mark R Denison

Pediatrics· June 2022

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Standardized two-step testing of antibody activity in COVID-19 convalescent plasma.
Pavlo Gilchuk, Isaac Thomsen, Sandra Yoder, Eric Brady, James D Chappell, Mark R Denison

iScience· January 2022

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Stabilized coronavirus spike stem elicits a broadly protective antibody.
Ching-Lin Hsieh, Anne P Werner, Sarah R Leist, Laura J Stevens, Ester Falconer, Mark R Denison

Cell Rep· November 2021

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Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.
Amarendra Pegu, Sarah E O'Connell, Stephen D Schmidt, Sijy O'Dell, Chloe A Talana, Mark R Denison

Science· September 2021

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Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
Matthew D Hall, James M Anderson, Annaliesa Anderson, David Baker, Jay Bradner, Mark Denison

J Infect Dis· July 2021

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Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage.
Sydni Caet Smith, Jennifer Gribble, Julia R Diller, Michelle A Wiebe, Timothy W Thoner, Mark R Denison

J Virol· March 2021

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Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults.
Wesley H Self, Thomas G Stewart, Allison P Wheeler, Wissam El Atrouni, Amanda J Bistran-Hall, Mark R Denison

Res Sq· March 2021

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Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults.
Wesley H Self, Thomas G Stewart, Allison P Wheeler, Wissam El Atrouni, Amanda J Bistran-Hall, Mark R Denison

Trials· March 2021

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Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination.
Alicia T Widge, Nadine G Rouphael, Lisa A Jackson, Evan J Anderson, Paul C Roberts, Mark R Denison

N Engl J Med· January 2021

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The coronavirus proofreading exoribonuclease mediates extensive viral recombination.
Jennifer Gribble, Laura J Stevens, Maria L Agostini, Jordan Anderson-Daniels, James D Chappell, Mark R Denison

PLoS Pathog· January 2021

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Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.
Evan J Anderson, Nadine G Rouphael, Alicia T Widge, Lisa A Jackson, Paul C Roberts, Mark R Denison

N Engl J Med· December 2020

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