Publications by authors named "Mark E Adams"

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Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy.
Mark E Adams, Michael B Wallace, Toufike Kanouni, Nicholas Scorah, Shawn M O'Connell

Bioorg Med Chem Lett· April 2012

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Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.
Andrew R Hudson, Robert I Higuchi, Steven L Roach, Mark E Adams, Angela Vassar

Bioorg Med Chem Lett· March 2011

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Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.
Andrew R Hudson, Robert I Higuchi, Steven L Roach, Lino J Valdez, Mark E Adams

Bioorg Med Chem Lett· March 2011

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Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.
Steven L Roach, Robert I Higuchi, Andrew R Hudson, Mark E Adams, Peter M Syka

Bioorg Med Chem Lett· January 2011

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Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Michael B Wallace, Mark E Adams, Toufike Kanouni, Clifford D Mol, Douglas R Dougan

Bioorg Med Chem Lett· July 2010

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Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.
Steven L Roach, Robert I Higuchi, Mark E Adams, Yan Liu, Donald S Karanewsky

Bioorg Med Chem Lett· June 2008

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Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.
Robert I Higuchi, Anthony W Thompson, Jyun-Hung Chen, Thomas R Caferro, Marquis L Cummings, Mark E Adams

Bioorg Med Chem Lett· October 2007

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Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
Andrew R Hudson, Steven L Roach, Robert I Higuchi, Dean P Phillips, Reid P Bissonnette, Mark E Adams

J Med Chem· September 2007

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Identification of the motifs and amino acids in aggrecan G1 and G2 domains involved in product secretion.
Chris Kiani, Liwen Chen, Vivian Lee, Peng-Sheng Zheng, Yaojiong Wu, Mark E Adams

Biochemistry· June 2003

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Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation.
Vivian Lee, Liwen Chen, Frouz Paiwand, Liu Cao, Yaojiong Wu, Mark E Adams

J Biol Chem· June 2002

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Regional quantification of cartilage type II collagen and aggrecan messenger RNA in joints with early experimental osteoarthritis.
John Robert Matyas, Dingqiu Huang, May Chung, Mark E Adams

Arthritis Rheum· June 2002

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The folded modules of aggrecan G3 domain exert two separable functions in glycosaminoglycan modification and product secretion.
Liwen Chen, Yaojiong Wu, Vivian Lee, Chris Kiani, Mark E Adams

J Biol Chem· January 2002

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