Publications by authors named "Mark Fiers"

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The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.
Giulia Albertini, Magdalena Zielonka, Marie-Lynn Cuypers, An Snellinx, Ciana Xu, Mark Fiers

Nat Neurosci· November 2025

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Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency.
Katerina Konstantoulea, Meine Ramakers, Sarah C Borrie, Dries T'syen, Daan Moechars, Mark Fiers

bioRxiv· October 2025

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APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.
Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Mark Fiers

EMBO Mol Med· December 2024

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Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.
Amy F Lloyd, Anna Martinez-Muriana, Emma Davis, Michael J D Daniels, Pengfei Hou, Mark Fiers

Cell Rep· November 2024

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NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer's disease.
Amber Penning, Sarah Snoeck, Oxana Garritsen, Giorgia Tosoni, Amber Hof, Mark Fiers

Sci Rep· September 2024

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Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.
Anna Mallach, Magdalena Zielonka, Veerle van Lieshout, Yanru An, Jia Hui Khoo, Mark Fiers

Cell Rep· June 2024

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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.
Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Mark Fiers

Nat Neurosci· May 2024

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Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Mark Fiers

Mol Neurodegener· April 2024

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The γ-secretase substrate proteome and its role in cell signaling regulation.
Pengfei Hou, Magdalena Zielonka, Lutgarde Serneels, Anna Martinez-Muriana, Nicola Fattorelli, Mark Fiers

Mol Cell· November 2023

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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease.
Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Mark Fiers

Science· September 2023

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Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.
Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Mark Fiers

Nat Neurosci· June 2023

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microRNA-132 regulates gene expression programs involved in microglial homeostasis.
Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Mark Fiers

iScience· June 2023

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Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation.
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Mark Fiers

Cells· March 2023

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Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.
Disha Shah, Willy Gsell, Jérôme Wahis, Emma S Luckett, Tarik Jamoulle, Mark Fiers

Cell Rep· August 2022

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Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Hannah Walgrave, Sriram Balusu, Sarah Snoeck, Elke Vanden Eynden, Katleen Craessaerts, Mark Fiers

Cell Stem Cell· October 2021

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Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.
Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers

Nat Commun· July 2021

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Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans.
Nicola Thrupp, Carlo Sala Frigerio, Leen Wolfs, Nathan G Skene, Nicola Fattorelli, Mark Fiers

Cell Rep· September 2020

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Mark Fiers

Cell· August 2020

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Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology.
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Mark Fiers

EMBO Mol Med· March 2020

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Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Mark Fiers

Nat Neurosci· December 2019

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Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells.
Kim R Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Mark Fiers

Nat Commun· June 2019

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T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development.
Charles E de Bock, Michelle Down, Kinsha Baidya, Bram Sweron, Andrew W Boyd, Mark Fiers

Haematologica· May 2019

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The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Carlo Sala Frigerio, Leen Wolfs, Nicola Fattorelli, Nicola Thrupp, Iryna Voytyuk, Mark Fiers

Cell Rep· April 2019

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Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.
Christel Claes, Johanna Van Den Daele, Ruben Boon, Sarah Schouteden, Alessio Colombo, Mark Fiers

Alzheimers Dement· March 2019

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Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology.
Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Mark Fiers

Mol Neurodegener· October 2018

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