Publications by authors named "Ruben Boon"

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ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome.
Thomas L Clarke, Hyo Min Cho, Ilaria Ceppi, Boya Gao, Tribhuwan Yadav, Ruben Boon

Nat Cell Biol· June 2025

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The glutathione S-transferase Gstt1 drives survival and dissemination in metastases.
Christina M Ferrer, Hyo Min Cho, Ruben Boon, Tiziano Bernasocchi, Lai Ping Wong

Nat Cell Biol· June 2024

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Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling.
Jonathan Sai-Hong Chui, Teresa Izuel-Idoype, Alessandra Qualizza, Rita Pires de Almeida, Lindsey Piessens, Ruben Boon

Adv Sci (Weinh)· February 2024

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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Samantha J Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D Sullivan, Matthew D Galbraith, Ruben Boon

Nat Metab· December 2023

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Automated Generation of hiPSC-Derived Hepatic Progeny by Cost-Efficient Compounds.
Gert Vanmarcke, Jonathan Sai-Hong Chui, Axelle Cooreman, Kristof De Vos, Lana Cleuren, Ruben Boon

Stem Cells· November 2023

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The Black Box of Technological Outcome Measures: An Example in Duchenne Muscular Dystrophy.
Karin J Naarding, Mariska M H P Janssen, Ruben D Boon, Paulina J M Bank, Robert P Matthew

J Neuromuscul Dis· July 2022

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A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Marta Moreno-Torres, Manoj Kumar, Guillem García-Llorens, Guillermo Quintás, Tine Tricot, Ruben Boon

J Proteome Res· March 2022

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Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings.
Tine Tricot, Hendrik Jan Thibaut, Kayvan Abbasi, Ruben Boon, Nicky Helsen

Biomedicines· January 2022

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Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption.
Ruben Boon

Front Genet· November 2021

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A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model.
Manoj Kumar, Burak Toprakhisar, Matthias Van Haele, Asier Antoranz, Ruben Boon

Biomaterials· September 2021

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Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes.
Bas Ter Braak, Marije Niemeijer, Ruben Boon, Céline Parmentier, Audrey Baze

Toxicol In Vitro· June 2021

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HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Raheem Fazal, Steven Boeynaems, Ann Swijsen, Mathias De Decker, Laura Fumagalli, Ruben Boon

EMBO J· April 2021

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A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.
Jee-Eun Choi, Carlos Sebastian, Christina M Ferrer, Caroline A Lewis, Moshe Sade-Feldman, Ruben Boon

Nat Metab· February 2021

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PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.
Jonathan De Smedt, Elise Anne van Os, Irene Talon, Sreya Ghosh, Burak Toprakhisar, Ruben Boon

Cell Death Dis· January 2021

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Nuclear metabolism and the regulation of the epigenome.
Ruben Boon, Giorgia G Silveira, Raul Mostoslavsky

Nat Metab· November 2020

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Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines.
Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas

Nat Commun· March 2020

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Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Ruben Boon

Nature· April 2019

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Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.
Christel Claes, Johanna Van Den Daele, Ruben Boon, Sarah Schouteden, Alessio Colombo

Alzheimers Dement· March 2019

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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ruben Boon

Nature· February 2019

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Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
Mar Coll, Luis Perea, Ruben Boon, Sofia B Leite, Julia Vallverdú

Cell Stem Cell· July 2018

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SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
Juan Antonio García-León, Manoj Kumar, Ruben Boon, David Chau, Jennifer One

Stem Cell Reports· February 2018

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Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.
Laura Ordovás, Ruben Boon, Mariaelena Pistoni, Yemiao Chen, Esther Wolfs

Stem Cell Reports· February 2018

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Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate.
Mariaelena Pistoni, Nicky Helsen, Jolien Vanhove, Ruben Boon, Zhuofei Xu

PLoS One· November 2017

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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
Wenting Guo, Maximilian Naujock, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Ruben Boon

Nat Commun· October 2017

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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli

Nat Commun· May 2017

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