Publications by authors named "Matthew D Galbraith"

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Blood measure of neuronal death is exponentially higher with age, especially in females, and halted in Alzheimer's disease by GM-CSF treatment.
Stefan H Sillau, Christina Coughlan, Md Mahiuddin Ahmed, Kavita Nair, Paula Araya, Matthew D Galbraith

Cell Rep Med· December 2025

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An integrated multi-omic natural history study of human development, sexual dimorphism, and the effects of trisomy 21.
Neetha Paul Eduthan, Micah G Donovan, Paula Araya, Angela L Rachubinski, Kelly D Sullivan, Matthew D Galbraith

Nat Commun· September 2025

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Interferon signaling modulates Down syndrome-associated Alzheimer's disease pathology in a mouse model.
Paula Araya, Brian Niemeyer, Kyndal Schade, Lauren N Dunn, Katherine Waugh, Matthew D Galbraith

iScience· August 2025

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Altered Hepatic Metabolism in Down Syndrome.
Lauren N Dunn, Brian F Niemeyer, Neetha P Eduthan, Kyndal A Schade, Katherine A Waugh, Matthew D Galbraith

bioRxiv· May 2025

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Evidence of blood-brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder.
Jonathan D Santoro, Neetha Paul Eduthan, Mellad M Khoshnood, Saba Jafarpour, Natalie K Boyd, Matthew D Galbraith

Ann Clin Transl Neurol· April 2025

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NF-κB signaling directs a program of transient amplifications at innate immune response genes.
Michael P Ludwig, Jason R Wilson, Matthew D Galbraith, Nirajan Bhandari, Lauren N Dunn

bioRxiv· March 2025

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome.
Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Matthew D Galbraith

Elife· February 2025

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Metabolic dysfunction mediated by HIF-1α contributes to epithelial differentiation defects in eosinophilic esophagitis.
Sinéad Ryan, Louise Crowe, Sofía N Almeida Cruz, Matthew D Galbraith, Carol O'Brien

J Allergy Clin Immunol· December 2024

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Integrated analysis of immunometabolic interactions in Down syndrome.
Lucas A Gillenwater, Matthew D Galbraith, Angela L Rachubinski, Neetha Paul Eduthan, Kelly D Sullivan

Sci Adv· December 2024

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JAK inhibition decreases the autoimmune burden in Down syndrome.
Angela L Rachubinski, Elizabeth Wallace, Emily Gurnee, Belinda A Enriquez-Estrada, Kayleigh R Worek, Matthew D Galbraith

Elife· December 2024

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome.
Kira Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Matthew D Galbraith

bioRxiv· November 2024

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JAK inhibition decreases the autoimmune burden in Down syndrome.
Angela L Rachubinski, Elizabeth Wallace, Emily Gurnee, Belinda A Enriquez Estrada, Kayleigh R Worek, Matthew D Galbraith

medRxiv· October 2024

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Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome.
Micah G Donovan, Angela L Rachubinski, Keith P Smith, Paula Araya, Katherine A Waugh, Matthew D Galbraith

Cell Rep· August 2024

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Neuron loss in the brain starts in childhood, increases exponentially with age and is halted by GM-CSF treatment in Alzheimer's disease.
Stefan H Sillau, Christina Coughlan, Md Mahiuddin Ahmed, Kavita Nair, Paula Araya, Matthew D Galbraith

medRxiv· July 2024

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Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome.
Micah G Donovan, Neetha P Eduthan, Keith P Smith, Eleanor C Britton, Hannah R Lyford, Matthew D Galbraith

Nat Commun· June 2024

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Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment.
Angelo D'Alessandro, S Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Matthew D Galbraith

Haematologica· December 2023

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EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression.
Arthur R Wolin, Melanie Y Vincent, Taylor Hotz, Stephen C Purdy, Sheera R Rosenbaum, Matthew D Galbraith

Neuro Oncol· December 2023

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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Samantha J Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D Sullivan, Matthew D Galbraith

Nat Metab· December 2023

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Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway.
Michael P Ludwig, Matthew D Galbraith, Neetha Paul Eduthan, Amanda A Hill, Michael R Clay

Cancer Res· August 2023

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In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction.
Angelo D'Alessandro, S Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Matthew D Galbraith

Am J Hematol· July 2023

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Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model.
Katherine A Waugh, Ross Minter, Jessica Baxter, Congwu Chi, Matthew D Galbraith

Nat Genet· June 2023

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Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition.
Matthew D Galbraith, Angela L Rachubinski, Keith P Smith, Paula Araya, Katherine A Waugh

Sci Adv· June 2023

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Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatment.
Angelo D'Alessandro, S Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Matthew D Galbraith

bioRxiv· April 2023

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FAM193A is a positive regulator of p53 activity.
Maria M Szwarc, Anna L Guarnieri, Molishree Joshi, Huy N Duc, Madison C Laird, Matthew D Galbraith

Cell Rep· March 2023

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evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction.
Angelo D'Alessandro, S Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Matthew D Galbraith

bioRxiv· February 2023

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