Publications by authors named "Mark Gurden"

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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Simon J Anderhub, Grace Wing-Yan Mak, Mark D Gurden, Amir Faisal, Konstantinos Drosopoulos

Mol Cancer Ther· October 2019

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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
Mark D Gurden, Simon J Anderhub, Amir Faisal, Spiros Linardopoulos

Oncotarget· April 2018

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E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N Pemberton, Mark D Gurden

Cancer Discov· April 2018

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RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
Saoirse O Dolly, Mark D Gurden, Konstantinos Drosopoulos, Paul Clarke, Johann de Bono

Br J Cancer· September 2017

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Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Amir Faisal, Grace W Y Mak, Mark D Gurden, Cristina P R Xavier, Simon J Anderhub

Br J Cancer· April 2017

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Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Mark D Gurden, Isaac M Westwood, Amir Faisal, Sébastien Naud, Kwai-Ming J Cheung

Cancer Res· August 2015

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Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).
Sébastien Naud, Isaac M Westwood, Amir Faisal, Peter Sheldrake, Vassilios Bavetsias, Mark Gurden

J Med Chem· December 2013

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Evaluation of a general practitioner referral service for manual treatment of back and neck pain.
Mark Gurden, Marcel Morelli, Greg Sharp, Katie Baker, Nicola Betts

Prim Health Care Res Dev· July 2012

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Re-evaluating the role of Tao1 in the spindle checkpoint.
Frederick G Westhorpe, Maria A Diez, Mark D J Gurden, Anthony Tighe, Stephen S Taylor

Chromosoma· August 2010

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Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.
Mark D J Gurden, Andrew J Holland, Wouter van Zon, Anthony Tighe, Mailys A Vergnolle

J Cell Sci· February 2010

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