Publications by authors named "Peter Sheldrake"

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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake

PLoS One· September 2020

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Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
James A H Gilburt, Hajrah Sarkar, Peter Sheldrake, Julian Blagg, Liming Ying

Angew Chem Int Ed Engl· September 2017

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Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).
Sébastien Naud, Isaac M Westwood, Amir Faisal, Peter Sheldrake, Vassilios Bavetsias

J Med Chem· December 2013

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Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.
Cornelis Matijssen, M Cris Silva-Santisteban, Isaac M Westwood, Samerene Siddique, Vanessa Choi, Peter Sheldrake

Bioorg Med Chem· November 2012

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Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.
Vassilios Bavetsias, Simon Crumpler, Chongbo Sun, Sian Avery, Butrus Atrash, Peter W Sheldrake

J Med Chem· October 2012

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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
Simon R Stockwell, Georgina Platt, S Elaine Barrie, Georgia Zoumpoulidou, Robert H Te Poele, Peter Sheldrake

PLoS One· May 2012

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Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Stuart C Wilson, Butrus Atrash, Clare Barlow, Susan Eccles, Peter M Fischer, Peter Sheldrake

Bioorg Med Chem· November 2011

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Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements.
Jonathan M Large, Jane E Torr, Florence I Raynaud, Paul A Clarke, Angela Hayes, Peter Sheldrake

Bioorg Med Chem· January 2011

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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.
Florence I Raynaud, Suzanne A Eccles, Sonal Patel, Sonia Alix, Gary Box, Peter Sheldrake

Mol Cancer Ther· July 2009

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The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.
Nicola E Wilsher, Will J Court, Ruth Ruddle, Yvette M Newbatt, Wynne Aherne, Peter W Sheldrake

Drug Metab Dispos· July 2007

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Conformation analyses, dynamic behavior and amide bond distortions of medium-sized heterocycles. 1. Partially and fully reduced 1-benzazepines.
Maryiam Qadir, Jonathan Cobb, Peter W Sheldrake, Neil Whittall, Andrew J P White

J Org Chem· March 2005

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Conformation analyses, dynamic behavior, and amide bond distortions of medium-sized heterocycles. 2. Partially and fully reduced 1-benzazocines, benzazonines, and benzazecines.
Maryiam Qadir, Jonathan Cobb, Peter W Sheldrake, Neil Whittall, Andrew J P White

J Org Chem· March 2005

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Preparation of 5-Hydroxy-2-iodopyridine: A Refutation of Earlier Reports.
Peter W. Sheldrake, Laurence C. Powling, Pritpal K. Slaich

J Org Chem· May 1997

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