Publications by authors named "Sheelagh Frame"

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Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
Martin Luke Rennie, Mehmet Gundogdu, Connor Arkinson, Steven Liness, Sheelagh Frame

J Med Chem· September 2024

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Correction to: Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML.
Wittawat Chantkran, Ya-Ching Hsieh, Daniella Zheleva, Sheelagh Frame, Helen Wheadon

Cell Death Discov· July 2021

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Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML.
Wittawat Chantkran, Ya-Ching Hsieh, Daniella Zheleva, Sheelagh Frame, Helen Wheadon

Cell Death Discov· June 2021

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Targeting synovial fibroblast proliferation in rheumatoid arthritis (TRAFIC): an open-label, dose-finding, phase 1b trial.
Arthur G Pratt, Stefan Siebert, Michael Cole, Deborah D Stocken, Christina Yap, Sheelagh Frame

Lancet Rheumatol· May 2021

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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake

PLoS One· September 2020

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Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial.
Stefan Siebert, Arthur G Pratt, Deborah D Stocken, Miranda Morton, Amy Cranston, Sheelagh Frame

Medicine (Baltimore)· June 2020

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Data sharing reveals complexity in the westward spread of domestic animals across Neolithic Turkey.
Benjamin S Arbuckle, Sarah Whitcher Kansa, Eric Kansa, David Orton, Canan Çakırlar, Sheelagh Frame

PLoS One· May 2015

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Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies.
Christophe Le Tourneau, Sandrine Faivre, Valérie Laurence, Catherine Delbaldo, Karina Vera, Sheelagh Frame

Eur J Cancer· December 2010

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Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.
Angela B Y Hui, Shijun Yue, Wei Shi, Nehad M Alajez, Emma Ito, Sheelagh Frame

Clin Cancer Res· June 2009

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Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents.
Ian N Fleming, Morag Hogben, Sheelagh Frame, Steven J McClue, Simon R Green

Clin Cancer Res· July 2008

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FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.
Thilo Hagen, Darren A E Cross, Ainsley A Culbert, Andrew West, Sheelagh Frame

J Biol Chem· November 2006

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Targeting glycogen synthase kinase-3 in insulin signalling.
Sheelagh Frame, Daniella Zheleva

Expert Opin Ther Targets· June 2006

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Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
David E MacCallum, Jean Melville, Sheelagh Frame, Kathryn Watt, Sian Anderson

Cancer Res· June 2005

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Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event.
Adam Cole, Sheelagh Frame, Philip Cohen

Biochem J· January 2004

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Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin.
Guillermo Velasco, Chris Armstrong, Nick Morrice, Sheelagh Frame, Philip Cohen

FEBS Lett· September 2002

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