Publications by authors named "Mark Hellberg"

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Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel.
Rajkumar V Patil, Shouxi Xu, Alfred N van Hoek, Andrew Rusinko, Zixia Feng, Mark Hellberg

Chem Biol Drug Des· May 2016

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Ocular Hypotensive Response in Nonhuman Primates of (8R)-1-[(2S)-2-Aminopropyl]-8,9-dihydro-7H-pyrano[2,3-g]indazol-8-ol a Selective 5-HT2 Receptor Agonist.
Jesse A May, Najam A Sharif, Marsha A McLaughlin, Hwang-Hsing Chen, Bryon S Severns, Mark R Hellberg

J Med Chem· November 2015

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In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.
Hwang-Hsing Chen, Abdelmoulah Namil, Bryon Severns, Jennifer Ward, Curtis Kelly, Mark R Hellberg

Bioorg Med Chem Lett· April 2014

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Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress.
Robert J Collier, Yamini Patel, Elizabeth A Martin, Olga Dembinska, Mark Hellberg

Invest Ophthalmol Vis Sci· April 2011

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Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma.
Robert L Davis, Mehmet Kahraman, Thomas J Prins, Yan Beaver, Travis G Cook, Mark R Hellberg

Bioorg Med Chem Lett· June 2010

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Water-soluble PDE4 inhibitors for the treatment of dry eye.
Steven P Govek, Guy Oshiro, John V Anzola, Clay Beauregard, Jasmine Chen, Mark R Hellberg

Bioorg Med Chem Lett· May 2010

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2,3-Diaminopyrazines as Rho kinase inhibitors.
Alan J Henderson, Mark Hadden, Cheng Guo, Neema Douglas, Helene Decornez, Mark R Hellberg

Bioorg Med Chem Lett· February 2010

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Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.
Zixia Feng, Mark R Hellberg, Najam A Sharif, Marsha A McLaughlin, Gary W Williams

Bioorg Med Chem· January 2009

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Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure.
Wan-Heng Wang, Loretta G McNatt, Iok-Hou Pang, J Cameron Millar, Peggy E Hellberg, Mark H Hellberg

J Clin Invest· March 2008

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Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Zixia Feng, Suchismita Mohapatra, Peter G Klimko, Mark R Hellberg, Jesse A May

Bioorg Med Chem Lett· June 2007

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Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage.
Iok-Hou Pang, Elaine C Johnson, Lijun Jia, William O Cepurna, Allan R Shepard, Mark R Hellberg

Invest Ophthalmol Vis Sci· April 2005

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Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Richard A Glennon, Mikhail L Bondarev, Nantaka Khorana, Richard Young, Jesse A May, Mark R Hellberg

J Med Chem· November 2004

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AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.
Robert D Selliah, Mark R Hellberg, Najam A Sharif, Marsha A McLaughlin, Gary W Williams

Bioorg Med Chem Lett· September 2004

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15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives.
Peter Klimko, Mark Hellberg, Marsha McLaughlin, Najam Sharif, Bryon Severns

Bioorg Med Chem· July 2004

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Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys.
Jesse A May, Marsha A McLaughlin, Najam A Sharif, Mark R Hellberg, Thomas R Dean

J Pharmacol Exp Ther· July 2003

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The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.
Mark R Hellberg, Tai-Lee Ke, Karen Haggard, Peter G Klimko, Tom R Dean

J Ocul Pharmacol Ther· April 2003

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Characterization of the in vitro anti-inflammatory activity of AL-5898 and related benzopyranyl esters and amides.
Karen C David, Milton T Brady, Lori K Weimer, Mark R Hellberg, Jon C Nixon

Inflammation· February 2003

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Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.
Mark R Hellberg, Marsha A McLaughlin, Naj A Sharif, Louis DeSantis, Tom R Dean

Surv Ophthalmol· August 2002

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3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.
Mark R Hellberg, Raymond E Conrow, Najam A Sharif, Marsha A McLaughlin, John E Bishop

Bioorg Med Chem· June 2002

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