Publications by authors named "Marsha McLaughlin"

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Effects of Rho Kinase Inhibitors on Intraocular Pressure and Aqueous Humor Dynamics in Nonhuman Primates and Rabbits.
Carol B Toris, Marsha A McLaughlin, Douglas P Dworak, Shan Fan, Shane Havens

J Ocul Pharmacol Ther· October 2017

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Ocular Hypotensive Response in Nonhuman Primates of (8R)-1-[(2S)-2-Aminopropyl]-8,9-dihydro-7H-pyrano[2,3-g]indazol-8-ol a Selective 5-HT2 Receptor Agonist.
Jesse A May, Najam A Sharif, Marsha A McLaughlin, Hwang-Hsing Chen, Bryon S Severns

J Med Chem· November 2015

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In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.
Hwang-Hsing Chen, Abdelmoulah Namil, Bryon Severns, Jennifer Ward, Curtis Kelly, Marsha A McLaughlin

Bioorg Med Chem Lett· April 2014

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Dose response for travoprost® in the glaucomatous beagle.
Edward O Mackay, Marsha McLaughlin, Caryn E Plummer, Anna Ben-Shlomo, Kirk N Gelatt

Vet Ophthalmol· March 2012

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Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension.
Carol B Toris, Justin M Risma, Janis Gonzales-Martinez, Marsha A McLaughlin, William W Dawson

Exp Eye Res· December 2010

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In vivo comparative study of ocular vasodilation, a relative indicator of hyperemia, in guinea pigs following treatment with bimatoprost ophthalmic solutions 0.01% and 0.03%.
Abayomi B Ogundele, David Earnest, Marsha A McLaughlin

Clin Ophthalmol· July 2010

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Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma.
Robert L Davis, Mehmet Kahraman, Thomas J Prins, Yan Beaver, Travis G Cook, Marsha A McLaughlin

Bioorg Med Chem Lett· June 2010

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2,3-Diaminopyrazines as Rho kinase inhibitors.
Alan J Henderson, Mark Hadden, Cheng Guo, Neema Douglas, Helene Decornez, Marsha McLaughlin

Bioorg Med Chem Lett· February 2010

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Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes.
Najam A Sharif, Marsha A McLaughlin, Curtis R Kelly, Parvaneh Katoli, Colene Drace

Exp Eye Res· March 2009

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Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.
Zixia Feng, Mark R Hellberg, Najam A Sharif, Marsha A McLaughlin, Gary W Williams

Bioorg Med Chem· January 2009

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Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Zixia Feng, Suchismita Mohapatra, Peter G Klimko, Mark R Hellberg, Jesse A May, Marsha A McLaughlin

Bioorg Med Chem Lett· June 2007

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AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist.
Najam A Sharif, Marsha A McLaughlin, Curtis R Kelly

J Ocul Pharmacol Ther· February 2007

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Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog.
Najam A Sharif, Marsha A McLaughlin, Curtis R Kelly, Shouxi Xu, Julie Y Crider

J Ocul Pharmacol Ther· October 2006

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Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction.
Najam A Sharif, Curtis R Kelly, Marsha McLaughlin

Invest Ophthalmol Vis Sci· September 2006

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Effects of a prostaglandin DP receptor agonist, AL-6598, on aqueous humor dynamics in a nonhuman primate model of glaucoma.
Carol B Toris, Gui-Lin Zhan, Michael R Feilmeier, Carl B Camras, Marsha A McLaughlin

J Ocul Pharmacol Ther· April 2006

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1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Jesse A May, Anura P Dantanarayana, Paul W Zinke, Marsha A McLaughlin, Najam A Sharif

J Med Chem· January 2006

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Effects of travoprost on aqueous humor dynamics in monkeys.
Carol B Toris, Gui-Lin Zhan, Carl B Camras, Marsha A McLaughlin

J Glaucoma· February 2005

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Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Richard A Glennon, Mikhail L Bondarev, Nantaka Khorana, Richard Young, Jesse A May, Marsha A McLaughlin

J Med Chem· November 2004

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AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.
Robert D Selliah, Mark R Hellberg, Najam A Sharif, Marsha A McLaughlin, Gary W Williams

Bioorg Med Chem Lett· September 2004

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15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives.
Peter Klimko, Mark Hellberg, Marsha McLaughlin, Najam Sharif, Bryon Severns

Bioorg Med Chem· July 2004

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Effects of brinzolamide on aqueous humor dynamics in monkeys and rabbits.
Carol B Toris, Gui-Lin Zhan, Marsha A McLaughlin

J Ocul Pharmacol Ther· October 2003

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A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Jesse A May, Hwang-Hsing Chen, Andrew Rusinko, Vincent M Lynch, Najam A Sharif, Marsha A McLaughlin

J Med Chem· September 2003

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Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys.
Jesse A May, Marsha A McLaughlin, Najam A Sharif, Mark R Hellberg, Thomas R Dean

J Pharmacol Exp Ther· July 2003

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Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.
Mark R Hellberg, Marsha A McLaughlin, Naj A Sharif, Louis DeSantis, Tom R Dean

Surv Ophthalmol· August 2002

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A new method and device to induce transient retinal ischemia in the rat.
Bing Li, Iok-Hou Pang, George Barnes, Marsha McLaughlin, William Holt

Curr Eye Res· June 2002

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