Publications by authors named "Mark L Paddock"

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A Combined Computational and Genetic Approach Uncovers Network Interactions of the Cyanobacterial Circadian Clock.
Joseph S Boyd, Ryan R Cheng, Mark L Paddock, Cigdem Sancar, Faruck Morcos

J Bacteriol· September 2016

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Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis.
Colin H Lipper, Mark L Paddock, José N Onuchic, Ron Mittler, Rachel Nechushtai

PLoS One· June 2016

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Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells.
Sarah H Holt, Merav Darash-Yahana, Yang Sung Sohn, Luhua Song, Ola Karmi, Mark L Paddock

J Cell Sci· January 2016

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High-throughput and quantitative approaches for measuring circadian rhythms in cyanobacteria using bioluminescence.
Ryan K Shultzaberger, Mark L Paddock, Takeo Katsuki, Ralph J Greenspan, Susan S Golden

Methods Enzymol· October 2015

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Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.
Sagi Tamir, Mark L Paddock, Merav Darash-Yahana-Baram, Sarah H Holt, Yang Sung Sohn

Biochim Biophys Acta· June 2015

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The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.
Fang Bai, Faruck Morcos, Yang-Sung Sohn, Merav Darash-Yahana, Celso O Rezende, Mark L Paddock

Proc Natl Acad Sci U S A· March 2015

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A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Sagi Tamir, Yael Eisenberg-Domovich, Andrea R Conlan, Jason T Stofleth, Colin H Lipper, Mark L Paddock

Acta Crystallogr D Biol Crystallogr· June 2014

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Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs.
Sagi Tamir, John A Zuris, Lily Agranat, Colin H Lipper, Andrea R Conlan, Mark L Paddock

PLoS One· April 2014

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Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
Sagi Tamir, Shahar Rotem-Bamberger, Chen Katz, Faruck Morcos, Kendra L Hailey, Mark L Paddock

Proc Natl Acad Sci U S A· April 2014

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Active output state of the Synechococcus Kai circadian oscillator.
Mark L Paddock, Joseph S Boyd, Dawn M Adin, Susan S Golden

Proc Natl Acad Sci U S A· October 2013

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NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
Yang-Sung Sohn, Sagi Tamir, Luhua Song, Dorit Michaeli, Imad Matouk, Mark L Paddock

Proc Natl Acad Sci U S A· September 2013

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Allosteric control in a metalloprotein dramatically alters function.
Elizabeth Leigh Baxter, John A Zuris, Charles Wang, Phu Luong T Vo, Herbert L Axelrod, Mark L Paddock

Proc Natl Acad Sci U S A· January 2013

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Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism.
Rachel Nechushtai, Andrea R Conlan, Yael Harir, Luhua Song, Ohad Yogev, Mark L Paddock

Plant Cell· May 2012

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NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein.
John A Zuris, Syed S Ali, Howard Yeh, Tung A Nguyen, Rachel Nechushtai, Mark L Paddock

J Biol Chem· April 2012

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Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein.
John A Zuris, Yael Harir, Andrea R Conlan, Maya Shvartsman, Dorit Michaeli, Mark L Paddock

Proc Natl Acad Sci U S A· August 2011

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Mutation of the His ligand in mitoNEET stabilizes the 2Fe-2S cluster despite conformational heterogeneity in the ligand environment.
Andrea R Conlan, Mark L Paddock, Christina Homer, Herbert L Axelrod, Aina E Cohen

Acta Crystallogr D Biol Crystallogr· June 2011

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Electron-nuclear and electron-electron double resonance spectroscopies show that the primary quinone acceptor QA in reaction centers from photosynthetic bacteria Rhodobacter sphaeroides remains in the same orientation upon light-induced reduction.
Marco Flores, Anton Savitsky, Mark L Paddock, Edward C Abresch, Alexander A Dubinskii

J Phys Chem B· December 2010

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Engineering the redox potential over a wide range within a new class of FeS proteins.
John A Zuris, Danny A Halim, Andrea R Conlan, Edward C Abresch, Rachel Nechushtai, Mark L Paddock

J Am Chem Soc· September 2010

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Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET.
Michelle M Dicus, Andrea Conlan, Rachel Nechushtai, Patricia A Jennings, Mark L Paddock

J Am Chem Soc· February 2010

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Electron transfer from cytochrome c(2) to the reaction center: a transition state model for ionic strength effects due to neutral mutations.
Edward C Abresch, Xiao-Min Gong, Mark L Paddock, Melvin Y Okamura

Biochemistry· December 2009

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Redox characterization of the FeS protein MitoNEET and impact of thiazolidinedione drug binding.
Daniel W Bak, John A Zuris, Mark L Paddock, Patricia A Jennings, Sean J Elliott

Biochemistry· November 2009

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Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.
Andrea R Conlan, Herbert L Axelrod, Aina E Cohen, Edward C Abresch, John Zuris, Mark L Paddock

J Mol Biol· September 2009

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The novel 2Fe-2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain.
Andrea R Conlan, Mark L Paddock, Herbert L Axelrod, Aina E Cohen, Edward C Abresch

Acta Crystallogr Sect F Struct Biol Cryst Commun· July 2009

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Resonance Raman studies of the (His)(Cys)3 2Fe-2S cluster of MitoNEET: comparison to the (Cys)4 mutant and implications of the effects of pH on the labile metal center.
Timothy F Tirrell, Mark L Paddock, Andrea R Conlan, Eric J Smoll, Rachel Nechushtai

Biochemistry· June 2009

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Identification of FTIR bands due to internal water molecules around the quinone binding sites in the reaction center from Rhodobacter sphaeroides.
Tatsuya Iwata, Mark L Paddock, Melvin Y Okamura, Hideki Kandori

Biochemistry· February 2009

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