Publications by authors named "Mark Labow"

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The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice.
Michael T Bocker, Grigorios Fanourgakis, Kristie Wetzel, Pavel A Komarov, Hélène Royo, Mark A Labow

Nat Commun· July 2025

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High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.
Maartje J Luteijn, Varun Bhaskar, Dominic Trojer, Melanie Schürz, Hicham Mahboubi, Mark Labow

Nucleic Acids Res· April 2025

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A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins.
Evan Casalino, Laurel B Stine, Aaron J Corin, Chuong-Thu Thai, Jose Quiroz, Mark Labow

SLAS Discov· September 2022

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Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons.
Mary E Matyskiela, Jinyi Zhu, Joshua M Baughman, Thomas Clayton, Michelle Slade, Mark Labow

ACS Chem Biol· December 2020

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TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
Prashant B Shambharkar, Mark Bittinger, Brian Latario, ZhaoHui Xiong, Somnath Bandyopadhyay, Mark A Labow

PLoS One· March 2016

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Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.
Deborah M Rothman, Xiaolin Gao, Elizabeth George, Timothy Rasmusson, Diksha Bhatia, Mark Labow

Chem Biol· September 2015

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
William E Dowdle, Beat Nyfeler, Jane Nagel, Robert A Elling, Shanming Liu, Mark A Labow

Nat Cell Biol· November 2014

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A hypomorphic lsd1 allele results in heart development defects in mice.
Thomas B Nicholson, Anup K Singh, Hui Su, Sarah Hevi, Jing Wang, Mark Labow

PLoS One· December 2013

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PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.
Xinming Cai, Yongyao Xu, Atwood K Cheung, Ronald C Tomlinson, Abel Alcázar-Román, Mark A Labow

Chem Biol· July 2013

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Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
Adrian Britschgi, Anke Bill, Heike Brinkhaus, Christopher Rothwell, Ieuan Clay, Mark Labow

Proc Natl Acad Sci U S A· March 2013

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Retraction: Defective heart development in hypomorphic LSD1 mice.
Thomas B Nicholson, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mark Labow

Cell Res· April 2012

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Defective heart development in hypomorphic LSD1 mice.
Thomas B Nicholson, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mark Labow

Cell Res· December 2011

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Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling.
Jian Chen, Qiong Shen, Mark Labow, L Alex Gaither

Cancer Res· June 2011

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The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.
Marie Gottar-Guillier, Francis Dodeller, Dieter Huesken, Vadim Iourgenko, Craig Mickanin, Mark Labow

J Immunol· May 2011

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KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation.
Felix Lohmann, Joseph Loureiro, Hui Su, Qing Fang, Hong Lei, Mark Labow

Stem Cells· February 2010

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Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.
Jason Borawski, Philip Troke, Xiaoling Puyang, Veronica Gibaja, Shanchaun Zhao, Mark Labow

J Virol· October 2009

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Identification of novel genes and pathways regulating SREBP transcriptional activity.
Sandipan Chatterjee, Joseph D Szustakowski, Nirmala R Nanguneri, Craig Mickanin, Mark A Labow

PLoS One· July 2009

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Cholesterol biosynthesis modulation regulates dengue viral replication.
Christopher Rothwell, Aude Lebreton, Chuan Young Ng, Joanne Y H Lim, Wei Liu, Mark Labow

Virology· June 2009

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Role for Med12 in regulation of Nanog and Nanog target genes.
Antonin V Tutter, Michael P Kowalski, Gretchen A Baltus, Vadim Iourgenko, Mark Labow

J Biol Chem· February 2009

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Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Daniel W Young, Andreas Bender, Jonathan Hoyt, Elizabeth McWhinnie, Gung-Wei Chirn, Mark Labow

Nat Chem Biol· January 2008

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A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.
Alex Gaither, Dale Porter, Yao Yao, Jason Borawski, Guang Yang, Mark Labow

Cancer Res· December 2007

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Optimization procedure for small interfering RNA transfection in a 384-well format.
Jason Borawski, Alicia Lindeman, Frank Buxton, Mark Labow, L Alex Gaither

J Biomol Screen· June 2007

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Genome-wide functional analysis of human cell-cycle regulators.
Mridul Mukherji, Russell Bell, Lubica Supekova, Yan Wang, Anthony P Orth, Mark Labow

Proc Natl Acad Sci U S A· October 2006

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Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
Zhidan Wu, Xueming Huang, Yajun Feng, Christoph Handschin, Yan Feng, Mark Labow

Proc Natl Acad Sci U S A· September 2006

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The application of systems biology to drug discovery.
Carolyn R Cho, Mark Labow, Mischa Reinhardt, Jan van Oostrum, Manuel C Peitsch

Curr Opin Chem Biol· August 2006

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