Publications by authors named "Mark Miedel"

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Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective.
Mark T Miedel, Mark E Schurdak, Andrew M Stern, Alejandro Soto-Gutierrez, Eric von Strobl

Semin Liver Dis· December 2025

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PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes.
Rodrigo M Florentino, Olamide Animasahun, Nils Haep, Minal Nenwani, Kehinde Omoloja, Mark Miedel

JCI Insight· December 2025

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Recapitulation of clinical and molecular hallmarks of lipid-induced hepatic insulin resistance in a zonated, vascularized human liver acinus microphysiological system during metabolic dysfunction-associated steatotic liver disease (MASLD) progression.
Julio Aleman, Lawrence Vernetti, Mark E Schurdak, Richard DeBiasio, Greg LaRocca, Mark T Miedel

bioRxiv· November 2025

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Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant.
Lanuza A P Faccioli, Yiyue Sun, Olamide Animasahun, Takashi Motomura, Zhenghao Liu, Mark T Miedel

Hepatology· September 2025

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Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata.
Mark T Miedel, Mahboubeh Varmazyad, Mengying Xia, Maria Mori Brooks, Dillon C Gavlock

Cell Rep Methods· April 2025

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A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
Julio Aleman, Ravikumar K, Connor Wiegand, Mark E Schurdak, Lawrence Vernetti, Mark T Miedel

Commun Biol· October 2024

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Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.
Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacín, Dillon C Gavlock, Richard DeBiasio, Mark T Miedel

Front Cell Dev Biol· September 2024

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Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
Mengying Xia, Maboubeh Varmazyad, Iris Pla Palacin, Dillon C Gavlock, Richard Debiasio, Mark Miedel

bioRxiv· May 2024

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A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
Julio Aleman, K Ravikumar, Connor Wiegand, Mark E Schurdak, Lawrence Vernetti, Mark T Miedel

bioRxiv· April 2024

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Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.
Vinny Negi, Dillon Gavlock, Mark T Miedel, Jeong Kyung Lee, Tongying Shun

Lab Chip· October 2023

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Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease.
Zehra N Kocas-Kilicarslan, Zeliha Cetin, Lanuza A P Faccioli, Takashi Motomura, Sriram Amirneni, Mark T Miedel

Gastro Hep Adv· October 2023

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Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.
Lanuza A P Faccioli, Zeliha Cetin, Zehra N Kocas-Kilicarslan, Kimberly Ortiz, Yiyue Sun, Mark T Miedel

Int J Mol Sci· August 2023

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
James J Beaudoin, Lara Clemens, Mark T Miedel, Albert Gough, Fatima Zaidi

Int J Mol Sci· June 2023

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A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies.
Daniel E Lefever, Mark T Miedel, Fen Pei, Johanna K DiStefano, Richard Debiasio

Metabolites· June 2022

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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Cliff J Luke, Stephanie Markovina, Misty Good, Ira E Wight, Brian J Thomas, Mark T Miedel

Commun Biol· January 2022

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Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors.
Manush Saydmohammed, Anupma Jha, Vineet Mahajan, Dillon Gavlock, Tong Ying Shun, Mark T Miedel

Exp Biol Med (Maywood)· November 2021

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A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®.
Kristin M Bircsak, Richard DeBiasio, Mark Miedel, Alaa Alsebahi, Ryan Reddinger

Toxicology· February 2021

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Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System.
Mark T Miedel, Dillon C Gavlock, Shanhang Jia, Albert Gough, D Lansing Taylor

Sci Rep· June 2019

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Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.
Shanhang Jia, Mark T Miedel, Marilyn Ngo, Ryan Hessenius, Ning Chen

Oncology· March 2018

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Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.
Shujie Shi, Cliff J Luke, Mark T Miedel, Gary A Silverman, Thomas R Kleyman

J Biol Chem· July 2016

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Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency.
Erin E Cummings, Linda P O'Reilly, Dale E King, Richard M Silverman, Mark T Miedel

PLoS One· June 2016

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SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.
Jason Z Niehaus, Mark T Miedel, Misty Good, Allyson N Wyatt, Stephen C Pak

Biochemistry· November 2015

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The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.
Richard M Silverman, Erin E Cummings, Linda P O'Reilly, Mark T Miedel, Gary A Silverman

Genetics· May 2015

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A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.
Linda P O'Reilly, Olivia S Long, Murat C Cobanoglu, Joshua A Benson, Cliff J Luke, Mark T Miedel

Hum Mol Genet· October 2014

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A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.
Olivia S Long, Joshua A Benson, Joon Hyeok Kwak, Cliff J Luke, Sager J Gosai, Mark T Miedel

Hum Mol Genet· October 2014

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