Publications by authors named "Mark P Grillo"

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [C]aficamten following single oral dose administration to rats.
Mark P Grillo, Rajaa Sukhun, Mohammad Bashir, Luke Ashcraft, Bradley P Morgan

Xenobiotica· September 2024

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In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.
Rajaa Sukhun, Peadar Cremin, Donghong Xu, Jeanelle Zamora, Jennifer Cheung, Mark P Grillo

Xenobiotica· September 2024

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Preclinical and pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy.
Mark P Grillo, Svetlana Markova, Marc Evanchik, Marc Trellu, Patricia Moliner

Xenobiotica· February 2021

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In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin.
Mark P Grillo, John C L Erve, Ryan Dick, James P Driscoll, Nicole Haste

Xenobiotica· June 2019

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Detecting reactive drug metabolites for reducing the potential for drug toxicity.
Mark P Grillo

Expert Opin Drug Metab Toxicol· March 2016

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Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Yingcai Wang, Richard Connors, Pingchen Fan, Xiaodong Wang, Zhongyu Wang, Mark P Grillo

Bioorg Med Chem Lett· July 2014

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Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists.
Yingcai Wang, Ming Yu, Jiang Zhu, Jian Ken Zhang, Frank Kayser, Mark P Grillo

Bioorg Med Chem Lett· February 2014

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Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists.
Ming Yu, Jian Ken Zhang, Yingcai Wang, Jiang Zhu, Frank Kayser, Mark P Grillo

Bioorg Med Chem Lett· January 2014

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Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.
Paul M Wehn, Paul E Harrington, Timothy J Carlson, James Davis, Pierre Deprez, Mark P Grillo

Bioorg Med Chem Lett· December 2013

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Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists.
Jian Ken Zhang, An-Rong Li, Ming Yu, Yingcai Wang, Jiang Zhu, Mark P Grillo

Bioorg Med Chem Lett· June 2013

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Interaction of γ-glutamyltranspeptidase with ibuprofen-S-acyl-glutathione in vitro and in vivo in human.
Mark P Grillo, Michelle Tadano Lohr, Smriti Khera

Drug Metab Dispos· January 2013

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Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.
Mark P Grillo, Michelle Tadano Lohr, Jill C M Wait

Drug Metab Dispos· August 2012

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Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes.
Eskouhie H Tchaparian, Jessica S Houghton, Craig Uyeda, Mark P Grillo, Lixia Jin

Drug Metab Dispos· December 2011

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Constituents in kava extracts potentially involved in hepatotoxicity: a review.
Line R Olsen, Mark P Grillo, Christian Skonberg

Chem Res Toxicol· July 2011

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Drug-S-acyl-glutathione thioesters: synthesis, bioanalytical properties, chemical reactivity, biological formation and degradation.
Mark P Grillo

Curr Drug Metab· March 2011

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Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.
Mark P Grillo, Jill C M Wait, Michelle Tadano Lohr, Smriti Khera, Leslie Z Benet

Drug Metab Dispos· January 2010

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Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes.
Mark P Grillo, Michelle Tadano Lohr

Drug Metab Dispos· May 2009

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Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.
Mark P Grillo, Fengmei Hua, Kristi L March, Leslie Z Benet, Charles G Knutson

Chem Res Toxicol· October 2008

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A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
Mark P Grillo, Ji Ma, Yohannes Teffera, Daniel J Waldon

Drug Metab Dispos· September 2008

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Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.
Mark P Grillo, Fengmei Hua

Chem Res Toxicol· September 2008

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Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats.
Chunze Li, Mark P Grillo, Ilaria Badagnani, Kimberly L Fife, Leslie Z Benet

Drug Metab Dispos· April 2008

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Metabolic activation of carboxylic acids.
Christian Skonberg, Jørgen Olsen, Kim Grimstrup Madsen, Steen Honoré Hansen, Mark P Grillo

Expert Opin Drug Metab Toxicol· April 2008

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Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile.
Mark P Grillo, Charles G Knutson, Phillip E Sanders, Daniel J Waldon, Fengmei Hua

Drug Metab Dispos· November 2003

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Identification of zomepirac-S-acyl-glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile.
Mark P Grillo, Fengmei Hua

Drug Metab Dispos· November 2003

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Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.
Mark P Grillo, Fengmei Hua, Charles G Knutson, Joseph A Ware, Chunze Li

Chem Res Toxicol· November 2003

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