Publications by authors named "Mark Safro"

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Breaking a single hydrogen bond in the mitochondrial tRNA -PheRS complex leads to phenotypic pleiotropy of human disease.
Moshe Peretz, Dmitry Tworowski, Ekaterine Kartvelishvili, John Livingston, Zofia Chrzanowska-Lightowlers, Mark Safro

FEBS J· September 2020

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Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
Ekaterine Kartvelishvili, Dmitry Tworowski, Hilary Vernon, Nina Moor, Jing Wang, Mark Safro

Protein Sci· August 2017

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Chimeric human mitochondrial PheRS exhibits editing activity to discriminate nonprotein amino acids.
Ekaterine Kartvelishvili, Moshe Peretz, Dmitry Tworowski, Nina Moor, Mark Safro

Protein Sci· March 2016

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Universal pathway for posttransfer editing reactions: insights from the crystal structure of TtPheRS with puromycin.
Dmitry Tworowski, Liron Klipcan, Moshe Peretz, Nina Moor, Mark G Safro

Proc Natl Acad Sci U S A· March 2015

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The mechanistic and evolutionary aspects of the 2'- and 3'-OH paradigm in biosynthetic machinery.
Mark Safro, Liron Klipcan

Biol Direct· July 2013

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Anticodon G recognition by tRNA synthetases mimics the tRNA core.
Liron Klipcan, Mark Safro, Paul Schimmel

Trends Biochem Sci· May 2013

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Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase.
Liron Klipcan, Igal Finarov, Nina Moor, Mark G Safro

J Amino Acids· August 2012

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Crystal structure of human mitochondrial PheRS complexed with tRNA(Phe) in the active "open" state.
Liron Klipcan, Nina Moor, Igal Finarov, Naama Kessler, Maria Sukhanova, Mark G Safro

J Mol Biol· January 2012

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Bacterial and eukaryotic phenylalanyl-tRNA synthetases catalyze misaminoacylation of tRNA(Phe) with 3,4-dihydroxy-L-phenylalanine.
Nina Moor, Liron Klipcan, Mark G Safro

Chem Biol· October 2011

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Common peptides study of aminoacyl-tRNA synthetases.
Assaf Gottlieb, Milana Frenkel-Morgenstern, Mark Safro, David Horn

PLoS One· September 2011

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Idiosyncrasy and identity in the prokaryotic Phe-system: crystal structure of E. coli phenylalanyl-tRNA synthetase complexed with phenylalanine and AMP.
Inbal Mermershtain, Igal Finarov, Liron Klipcan, Naama Kessler, Haim Rozenberg, Mark G Safro

Protein Sci· January 2011

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Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns.
Igal Finarov, Nina Moor, Naama Kessler, Liron Klipcan, Mark G Safro

Structure· March 2010

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'RNA walk' a novel approach to study RNA-RNA interactions between a small RNA and its target.
Yaniv Lustig, Chaim Wachtel, Mark Safro, Li Liu, Shulamit Michaeli

Nucleic Acids Res· January 2010

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Intra-protein compensatory mutations analysis highlights the tRNA recognition regions in aminoacyl-tRNA synthetases.
Milana Frenkel-Morgenstern, Dmitry Tworowski, Liron Klipcan, Mark Safro

J Biomol Struct Dyn· October 2009

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Large-scale movement of functional domains facilitates aminoacylation by human mitochondrial phenylalanyl-tRNA synthetase.
Srujana S Yadavalli, Liron Klipcan, Alexey Zozulya, Rajat Banerjee, Dmitri Svergun, Mark Safro

FEBS Lett· October 2009

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Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine.
Liron Klipcan, Nina Moor, Naama Kessler, Mark G Safro

Proc Natl Acad Sci U S A· July 2009

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Crystallization and X-ray analysis of human cytoplasmic phenylalanyl-tRNA synthetase.
Igal Finarov, Nina Moor, Naama Kessler, Mark Safro

Acta Crystallogr Sect F Struct Biol Cryst Commun· February 2009

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The tRNA-induced conformational activation of human mitochondrial phenylalanyl-tRNA synthetase.
Liron Klipcan, Inna Levin, Naama Kessler, Nina Moor, Igal Finarov, Mark Safro

Structure· July 2008

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Presence of tRNA-dependent pathways correlates with high cysteine content in methanogenic Archaea.
Liron Klipcan, Milana Frenkel-Morgenstern, Mark G Safro

Trends Genet· February 2008

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Enzymatic tRNA acylation by acid and alpha-hydroxy acid analogues of amino acids.
Alina Owczarek, Mark Safro, Alexey D Wolfson

Biochemistry· January 2008

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Purification, crystallization and preliminary X-ray characterization of a human mitochondrial phenylalanyl-tRNA synthetase.
Inna Levin, Naama Kessler, Nina Moor, Liron Klipcan, Emine Koc, Mark Safro

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2007

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The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end.
Nina Moor, Olga Kotik-Kogan, Dmitry Tworowski, Maria Sukhanova, Mark Safro

Biochemistry· September 2006

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Optimal growth temperature of prokaryotes correlates with class II amino acid composition.
Liron Klipcan, Ilya Safro, Boris Temkin, Mark Safro

FEBS Lett· March 2006

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Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase.
Olga Kotik-Kogan, Nina Moor, Dmitry Tworowski, Mark Safro

Structure· December 2005

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Electrostatic potential of aminoacyl-tRNA synthetase navigates tRNA on its pathway to the binding site.
Dmitry Tworowski, Anna V Feldman, Mark G Safro

J Mol Biol· July 2005

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