Publications by authors named "Markus Frericks"

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A Simple Framework for Collaborative Development of Predictive Models Trained on Proprietary Data.
Pablo Rodríguez-Belenguer, Alexander Amberg, Frank Bringezu, Markus Frericks, Jennifer Hemmerich

J Chem Inf Model· December 2025

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Evidence of erythropoiesis rather than direct genotoxicity causing micronucleus induction by a new protoporphyrinogen-oxidase inhibitor.
Naveed Honarvar, Astrid Zander, Miyuki Shigano, Eva Dony, Brandy Riffle, Markus Frericks

Mutat Res Genet Toxicol Environ Mutagen· October 2025

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The database makes the poison: How the selection of datasets in QSAR models impacts toxicant prediction of higher tier endpoints.
Lyle D Burgoon, Felix M Kluxen, Anja Hüser, Markus Frericks

Regul Toxicol Pharmacol· August 2024

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Computational prediction of the metabolites of agrochemicals formed in rats.
Vincent-Alexander Scholz, Conrad Stork, Markus Frericks, Johannes Kirchmair

Sci Total Environ· October 2023

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A new approach methodology using kinetically-derived maximum dose levels in risk assessment - A case study with afidopyropen.
Anne E Loccisano, Elaine Freeman, Adriana Doi, Markus Frericks, Ivana Fegert

Regul Toxicol Pharmacol· August 2023

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eTRANSAFE: data science to empower translational safety assessment.
Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Shoji Asakura, Markus Frericks

Nat Rev Drug Discov· August 2023

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Making in silico predictive models for toxicology FAIR.
Mark T D Cronin, Samuel J Belfield, Katharine A Briggs, Steven J Enoch, James W Firman, Markus Frericks

Regul Toxicol Pharmacol· May 2023

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Understanding and overcoming the technical challenges in using in silico predictions in regulatory decisions of complex toxicological endpoints - A pesticide perspective for regulatory toxicologists with a focus on machine learning models.
Lyle D Burgoon, Felix M Kluxen, Markus Frericks

Regul Toxicol Pharmacol· January 2023

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Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides.
Anastasia Weyrich, Madeleine Joel, Geertje Lewin, Thomas Hofmann, Markus Frericks

Birth Defects Res· August 2022

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Evaluating Confidence in Toxicity Assessments Based on Experimental Data and Predictions.
Candice Johnson, Lennart T Anger, Romualdo Benigni, David Bower, Frank Bringezu, Markus Frericks

Comput Toxicol· February 2022

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Ontogeny of renal, hepatic, and placental expression of ATP-binding cassette and solute carrier transporters in the rat and the rabbit.
Anastasia Weyrich, Markus Frericks, Michael Eichenlaub, Steffen Schneider, Thomas Hofmann

Reprod Toxicol· January 2022

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Approaches In Carcinogenicity Hazard Assessment: Current Status and Future Needs.
Raymond R Tice, Arianna Bassan, Alexander Amberg, Lennart T Anger, Marc A Beal, Markus Frericks

Comput Toxicol· November 2021

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Afidopyropen: Challenges and impact of a toxicokinetic study designed to identify a point of inflection from dose-proportionality.
Anne E Loccisano, Elaine Freeman, Brandy Riffle, Adriana Doi, Markus Frericks

Regul Toxicol Pharmacol· August 2021

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Use of toxicokinetic data for afidopyropen to determine the dose levels in developmental toxicity studies.
Anne E Loccisano, James Bus, Bhaskar Gollapudi, Brandy Riffle, Markus Frericks

Regul Toxicol Pharmacol· June 2020

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Genetic toxicology in silico protocol.
Catrin Hasselgren, Ernst Ahlberg, Yumi Akahori, Alexander Amberg, Lennart T Anger, Markus Frericks

Regul Toxicol Pharmacol· October 2019

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Uterine adenocarcinoma in the rat induced by afidopyropen. An analysis of the lesion's induction, progression and its relevance to humans.
Andrew Van Cott, Markus Frericks, Charles Hastings, Naveed Honarvar, Burkhard Flick

Regul Toxicol Pharmacol· June 2018

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The arylhydrocarbon receptor is only marginally involved in the antileukemic effects of its ligand curcumin.
Andreas Goergens, Markus Frericks, Charlotte Esser

Anticancer Res· November 2009

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A toolbox of novel murine house-keeping genes identified by meta-analysis of large scale gene expression profiles.
Markus Frericks, Charlotte Esser

Biochim Biophys Acta· December 2008

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Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response.
Markus Frericks, Lyle D Burgoon, Timothy R Zacharewski, Charlotte Esser

Toxicol Appl Pharmacol· October 2008

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Microarray analysis of the AHR system: tissue-specific flexibility in signal and target genes.
Markus Frericks, Marc Meissner, Charlotte Esser

Toxicol Appl Pharmacol· May 2007

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Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice.
Markus Frericks, Vladimir V Temchura, Marc Majora, Susanne Stutte, Charlotte Esser

Biol Chem· September 2006

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Detection of a novel population of fetal thymocytes characterized by preferential emigration and a TCRgammadelta+ T cell fate after dioxin exposure.
Marc Majora, Markus Frericks, Vladimir Temchura, Gaby Reichmann, Charlotte Esser

Int Immunopharmacol· November 2005

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Role of the aryl hydrocarbon receptor in thymocyte emigration in vivo.
Vladimir V Temchura, Markus Frericks, Wolfgang Nacken, Charlotte Esser

Eur J Immunol· September 2005

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