Publications by authors named "Markus Morkel"

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Elimination of CDX2 restricts intestinal hybrid differentiation signatures in stem cell-derived hepatocyte-like cells.
Patrick Nell, Antonia Thomitzek, David Feuerborn, Andreas Scholtz-Illigens, Sarah M Seidel, Markus Morkel

Stem Cell Res Ther· October 2025

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Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer.
Oleksandra Aust, Moritz R T Thiel, Eric Blanc, Mareen Lüthen, Viola Hollek, Markus Morkel

Sci Signal· July 2025

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Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.
Jana Ihlow, Livius Penter, Lam Giang Vuong, Philip Bischoff, Benedikt Obermayer, Markus Morkel

Med· April 2025

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GPA33 expression in colorectal cancer can be induced by WNT inhibition and targeted by cellular therapy.
Teresa Börding, Tobias Janik, Philip Bischoff, Markus Morkel, Christine Sers

Oncogene· January 2025

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High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment.
Tzu-Ting Wei, Eric Blanc, Stefan Peidli, Philip Bischoff, Alexandra Trinks, Markus Morkel

Int J Cancer· November 2024

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Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue.
Alexandra Trinks, Miha Milek, Dieter Beule, Julie Kluge, Stefan Florian, Markus Morkel

Cell Oncol (Dordr)· August 2024

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AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication.
Nanna Monjé, Mihnea P Dragomir, Bruno V Sinn, Inga Hoffmann, Anuar Makhmut, Markus Morkel

Br J Cancer· May 2024

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Oncogenic signaling is coupled to colorectal cancer cell differentiation state.
Thomas Sell, Christian Klotz, Matthias M Fischer, Rosario Astaburuaga-García, Susanne Krug, Markus Morkel

J Cell Biol· June 2023

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Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells.
Patrick Nell, Kathrin Kattler, David Feuerborn, Birte Hellwig, Adrian Rieck, Markus Morkel

J Hepatol· November 2022

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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Markus Morkel

PLoS Biol· November 2022

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Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis.
Carmen Aguilar, Mindaugas Pauzuolis, Malvika Pompaiah, Ehsan Vafadarnejad, Panagiota Arampatzi, Markus Morkel

Nat Commun· October 2022

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The single-cell transcriptional landscape of lung carcinoid tumors.
Philip Bischoff, Alexandra Trinks, Jennifer Wiederspahn, Benedikt Obermayer, Jan Patrick Pett, Markus Morkel

Int J Cancer· June 2022

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Triple Targeting of HER Receptors Overcomes Heregulin-mediated Resistance to EGFR Blockade in Colorectal Cancer.
Alexander Rau, Nicole Janssen, Lennart Kühl, Thomas Sell, Svetlana Kalmykova, Markus Morkel

Mol Cancer Ther· May 2022

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DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors.
Tincy Simon, Pamela Riemer, Armin Jarosch, Katharina Detjen, Annunziata Di Domenico, Markus Morkel

Genome Med· March 2022

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Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma.
Philip Bischoff, Alexandra Trinks, Benedikt Obermayer, Jan Patrick Pett, Jennifer Wiederspahn, Markus Morkel

Oncogene· December 2021

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Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Markus Morkel

EMBO Mol Med· October 2021

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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Markus Morkel

Nat Commun· June 2021

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PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress -Triggered Intestinal Tumor Formation.
Alexandra L Farrall, Matthias Lienhard, Christina Grimm, Heiner Kuhl, Susanna H M Sluka, Markus Morkel

Cancer Res· January 2021

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Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.
Soulafa Mamlouk, Tincy Simon, Laura Tomás, David C Wedge, Alexander Arnold, Markus Morkel

BMC Biol· September 2020

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SFPQ Depletion Is Synthetically Lethal with BRAF in Colorectal Cancer Cells.
Kathleen Klotz-Noack, Bertram Klinger, Maria Rivera, Natalie Bublitz, Florian Uhlitz, Markus Morkel

Cell Rep· September 2020

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Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.
Bastian Gastl, Kathleen Klotz-Noack, Bertram Klinger, Sylvia Ispasanie, Krenoula Hani Fouad Salib, Markus Morkel

Cell Death Dis· July 2020

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Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.
Nadine Rohwer, Sandra Jumpertz, Merve Erdem, Antje Egners, Klaudia T Warzecha, Markus Morkel

Oncogene· July 2019

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Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.
Raphael Brandt, Thomas Sell, Mareen Lüthen, Florian Uhlitz, Bertram Klinger, Markus Morkel

Nat Commun· July 2019

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Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer.
Felix Bormann, Sebastian Stinzing, Sascha Tierling, Markus Morkel, Maria Rivera Markelova

Int J Cancer· February 2019

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Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Sarah C Starossom, Juliana Campo Garcia, Tim Woelfle, Silvina Romero-Suarez, Marta Olah, Markus Morkel

Nat Commun· January 2019

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