Publications by authors named "Markus Trunzer"

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Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.
Angela Mackay, Juraj Velcicky, Nina Gommermann, Henri Mattes, Philipp Janser, Markus Trunzer

J Med Chem· December 2024

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Improving In Vitro-In Vivo Extrapolation of Clearance Using Rat Liver Microsomes for Highly Plasma Protein-Bound Molecules.
Markus Trunzer, Joana Teigão, Felix Huth, Birk Poller, Sandrine Desrayaud

Drug Metab Dispos· April 2024

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Deep Learning Models Compared to Experimental Variability for the Prediction of CYP3A4 Time-Dependent Inhibition.
Andrin Fluetsch, Markus Trunzer, Grégori Gerebtzoff, Raquel Rodríguez-Pérez

Chem Res Toxicol· April 2024

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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo.
Kenji Namoto, Clara Baader, Vanessa Orsini, Alexandro Landshammer, Eva Breuer, Markus Trunzer

Cell Stem Cell· April 2024

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Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.
Gebhard Thoma, Odile Decoret, Eric Vangrevelinghe, Markus Trunzer, Andrea Decker

J Med Chem· November 2023

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Multispecies Machine Learning Predictions of In Vitro Intrinsic Clearance with Uncertainty Quantification Analyses.
Raquel Rodríguez-Pérez, Markus Trunzer, Nadine Schneider, Bernard Faller, Grégori Gerebtzoff

Mol Pharm· January 2023

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Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery.
Joachim Blanz, Gareth Williams, Jerôme Dayer, Thierry Délémonté, Werner Gertsch, Markus Trunzer

J Mass Spectrom· April 2017

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An integrated approach for identification and target validation of antifungal compounds active against Erg11p.
Dominic Hoepfner, Shantanu Karkare, Stephen B Helliwell, Martin Pfeifer, Markus Trunzer

Antimicrob Agents Chemother· August 2012

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CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs.
Alfred Zimmerlin, Markus Trunzer, Bernard Faller

Drug Metab Dispos· June 2011

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Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.
Markus Trunzer, Bernard Faller, Alfred Zimmerlin

J Med Chem· January 2009

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Cytostar-T plates--a valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?
Michael Kiffe, Robert Nufer, Markus Trunzer, Daniel Graf

J Chromatogr A· July 2007

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Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer.
Markus Trunzer, Daniel Graf, Michael Kiffe

Rapid Commun Mass Spectrom· May 2007

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Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices.
Michael Kiffe, Daniel Graf, Markus Trunzer

Rapid Commun Mass Spectrom· May 2007

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