Publications by authors named "Martin A Lowe"

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Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials.
Annie Delaunois, Alvaro Cardenas, Teresa de Haro, Helga H J Gerets, Vitalina Gryshkova, Martin A Lowe

Toxicol Sci· October 2024

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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors.
Helga H J Gerets, Annie Delaunois, Alvaro Cardenas, Reiner Class, Renaud Fleurance, Martin A Lowe

Toxicol Sci· October 2024

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Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization.
Komei Sakata, Martin A Lowe, Mengyang Xuan, Jeffrey Bruffaerts, Luigi P Stasi

ACS Med Chem Lett· November 2023

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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of .
Martin A Lowe, Alvaro Cardenas, Jean-Pierre Valentin, Zhaoning Zhu, Jan Abendroth

J Med Chem· October 2022

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Fused thiophene derivatives as MEK inhibitors.
Victoria E Laing, Daniel C Brookings, Rachel J Carbery, Jose Gascon Simorte, Martin C Hutchings, Martin A Lowe

Bioorg Med Chem Lett· January 2012

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Palladium-mediated annulation of vinyl aziridines with Michael acceptors: stereocontrolled synthesis of substituted pyrrolidines and its application in a formal synthesis of (-)-α-kainic acid.
Martin A Lowe, Mehrnoosh Ostovar, Serena Ferrini, C Chun Chen, Paul G Lawrence

Angew Chem Int Ed Engl· July 2011

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