Publications by authors named "Martin Perreault"

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Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel.
René Maltais, Jenny Roy, Martin Perreault, Sachiko Sato, Julie-Christine Lévesque

Int J Mol Sci· October 2021

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Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer.
Simon Vézina-Dawod, Martin Perreault, Louis-David Guay, Nicolas Gerber, Stéphane Gobeil

Bioorg Med Chem· September 2021

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Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid.
Ariane Thérien, Anna Cieślak, Mélanie Verreault, Martin Perreault, Jocelyn Trottier

Nutrients· July 2021

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16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies.
Francisco Cortés-Benítez, Jenny Roy, Martin Perreault, René Maltais, Donald Poirier

J Steroid Biochem Mol Biol· June 2021

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Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.
René Maltais, Martin Perreault, Jenny Roy, Donald Poirier

Eur J Med Chem· February 2020

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Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines.
Raphaël Dutour, René Maltais, Martin Perreault, Jenny Roy, Donald Poirier

Anticancer Agents Med Chem· August 2019

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A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships.
Francisco Cortés-Benítez, Jenny Roy, Martin Perreault, René Maltais, Donald Poirier

J Med Chem· August 2019

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Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model.
Martin Perreault, René Maltais, Jenny Roy, Sylvain Picard, Ion Popa

Invest New Drugs· June 2019

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Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions.
Martin Perreault, Ewa Wunsch, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault

Can J Gastroenterol Hepatol· March 2019

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Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133.
Martin Perreault, René Maltais, Lucie Carolle Kenmogne, Danny Létourneau, Jean-Guy LeHoux

Pharmacol Res· February 2018

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Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1.
Alexandre Trottier, René Maltais, Diana Ayan, Xavier Barbeau, Jenny Roy, Martin Perreault

Biochem Pharmacol· November 2017

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Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models.
Martin Perreault, René Maltais, Jenny Roy, Raphaël Dutour, Donald Poirier

ChemMedChem· January 2017

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Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133.
Martin Perreault, René Maltais, Raphaël Dutour, Donald Poirier

Steroids· November 2016

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Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity.
René Maltais, Alexandre Trottier, Xavier Barbeau, Patrick Lagüe, Martin Perreault

J Steroid Biochem Mol Biol· July 2016

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Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction.
Martin Perreault, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron

PLoS One· February 2015

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The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.
Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron

Drug Metab Dispos· September 2013

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Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women.
Karine Blouin, Mélanie Nadeau, Martin Perreault, Alain Veilleux, Renée Drolet

Clin Endocrinol (Oxf)· February 2010

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Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.
Mélanie Verreault, Jenny Kaeding, Patrick Caron, Jocelyn Trottier, Laurent Grosse, Martin Perreault

Drug Metab Rev· February 2010

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The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.
Jocelyn Trottier, Diala El Husseini, Martin Perreault, Sophie Pâquet, Patrick Caron

J Biol Chem· January 2010

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