Publications by authors named "Martin R Higgs"

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A busy BOD1-y: the diverse functions of an intracellular signaling regulatory protein family.
Thomas J Kucharski, Martin R Higgs, Duane A Compton, Susanne Bechstedt

Biochem Soc Trans· December 2025

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SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells.
Ellie Sweatman, Rachel Bayley, Richad Selemane, Martin R Higgs

Br J Cancer· May 2025

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An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity.
Thomas J Kucharski, Irma M Vlasac, Tatiana Lyalina, Martin R Higgs, Brock C Christensen

Cell Rep· February 2025

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Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma.
Nicholas Davies, Tegan Francis, Ceri Oldreive, Maria Azam, Jordan Wilson, Martin R Higgs

Haematologica· December 2024

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An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity.
Thomas J Kucharski, Irma M Vlasac, Martin R Higgs, Brock C Christensen, Susanne Bechstedt

bioRxiv· March 2024

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Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.
Abhishek Bharadwaj Sharma, Muhammad Khairul Ramlee, Joel Kosmin, Martin R Higgs, Amy Wolstenholme

Nat Commun· November 2023

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C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.
Abhishek Bharadwaj Sharma, Muhammad Khairul Ramlee, Joel Kosmin, Martin R Higgs, Amy Wolstenholme

Nat Commun· August 2023

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Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency.
Christopher B Mahony, Lucy Copper, Pavle Vrljicak, Boris Noyvert, Chrystala Constantinidou, Martin R Higgs

Cell Rep· June 2023

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Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans.
Sally C Fletcher, Charlotte Hall, Tristan J Kennedy, Sander Pajusalu, Monica H Wojcik, Martin R Higgs

J Clin Invest· April 2023

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A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder.
Lot Snijders Blok, Jolijn Verseput, Dmitrijs Rots, Hanka Venselaar, A Micheil Innes, Martin R Higgs

HGG Adv· January 2023

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New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers.
Rachel Bayley, Ellie Sweatman, Martin R Higgs

Cancer Drug Resist· January 2023

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Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.
Laura J Grange, John J Reynolds, Farid Ullah, Bertrand Isidor, Robert F Shearer, Martin R Higgs

Nat Commun· November 2022

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ.
Rachel Bayley, Valerie Borel, Rhiannon J Moss, Ellie Sweatman, Philip Ruis, Martin R Higgs

Mol Cell· May 2022

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Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome.
Joost Kummeling, Diante E Stremmelaar, Nicholas Raun, Margot R F Reijnders, Marjolein H Willemsen, Martin R Higgs

Mol Psychiatry· June 2021

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Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M.
Jianming Wang, Patricia Rojas, Jingwen Mao, Martina Mustè Sadurnì, Olivia Garnier, Martin R Higgs

Cell Rep· February 2021

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Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability.
Reihaneh Zarrizi, Martin R Higgs, Karolin Voßgröne, Maria Rossing, Birgitte Bertelsen

J Clin Invest· August 2020

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Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.
Lindsay C Burrage, John J Reynolds, Nissan Vida Baratang, Jennifer B Phillips, Jeremy Wegner, Martin R Higgs

Am J Hum Genet· March 2019

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Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia.
Hae Ryung Chang, Sung Yoon Cho, Jae Hoon Lee, Eunkyung Lee, Jieun Seo, Martin R Higgs

Am J Hum Genet· March 2019

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MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.
Rachel Bayley, Daniel Blakemore, Laila Cancian, Stephanie Dumon, Giacomo Volpe, Martin R Higgs

Cancer Res· October 2018

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On your marks, get SET(D1A): the race to protect stalled replication forks.
Shabana Begum, Amalia Goula, Rachel Bayley, Martin R Higgs

Mol Cell Oncol· October 2018

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Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.
Martin R Higgs, Koichi Sato, John J Reynolds, Shabana Begum, Rachel Bayley

Mol Cell· July 2018

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PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.
George E Ronson, Ann Liza Piberger, Martin R Higgs, Anna L Olsen, Grant S Stewart

Nat Commun· February 2018

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Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice.
Hervé Lerat, Mohamed Rabah Imache, Jacqueline Polyte, Aurore Gaudin, Marion Mercey, Martin R Higgs

J Biol Chem· August 2017

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Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.
John J Reynolds, Louise S Bicknell, Paula Carroll, Martin R Higgs, Ranad Shaheen

Nat Genet· April 2017

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Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein.
Elizabeth K Marsh, Craig P Delury, Nicholas J Davies, Christopher J Weston, Mohammed A L Miah, Martin R Higgs

Oncotarget· March 2017

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