Publications by authors named "Martin Thoolen"

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Enhanced Vatiquinone Bioavailability With Fatty Meals and Optimal Dosing Schedule.
Lucy Lee, Katsuyuki Murase, Martin Thoolen, Peter Giannousis, Diksha Kaushik

Biopharm Drug Dispos· September 2025

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Effect of Itraconazole, a CYP3A4 Inhibitor, and Rifampin, a CYP3A4 Inducer, on the Pharmacokinetics of Vatiquinone.
Lucy Lee, Martin Thoolen, Jiyuan Ma, Diksha Kaushik, Lee Golden

Clin Pharmacol Drug Dev· December 2024

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Absorption, distribution, metabolism and excretion of C-vatiquinone in rats, dogs, and human subjects.
Jiyuan Ma, Lucy Lee, Bert Yao, Peter Giannousis, Martin Thoolen

Xenobiotica· May 2023

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Clinical Drug-Drug Interaction Between Vatiquinone, a 15-Lipoxygenase Inhibitor, and Rosuvastatin, a Breast Cancer Resistance Protein Substrate.
Lucy Lee, Katsuyuki Murase, Jiyuan Ma, Martin Thoolen

Clin Pharmacol Drug Dev· March 2023

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First-in-Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15-Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis.
Lan Gao, Peter Giannousis, Martin Thoolen, Diksha Kaushik, Joey Latham

Clin Pharmacol Drug Dev· February 2023

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Evaluation of vatiquinone drug-drug interaction potential in vitro and in a phase 1 clinical study with tolbutamide, a CYP2C9 substrate, and omeprazole, a CYP2C19 substrate, in healthy subjects.
Katsuyuki Murase, Lucy Lee, Jiyuan Ma, Rosemary Barrett, Martin Thoolen

Eur J Clin Pharmacol· November 2022

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Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Joshua P Taygerly, Lawrence R McGee, Steven M Rubenstein, Jonathan B Houze, Timothy D Cushing, Martin Thoolen

Bioorg Med Chem· February 2013

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Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial disease.
Francis G Blankenberg, Stephen L Kinsman, Bruce H Cohen, Michael L Goris, Kenneth M Spicer, Martin Thoolen

Mol Genet Metab· December 2012

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EPI-743 reverses the progression of the pediatric mitochondrial disease--genetically defined Leigh Syndrome.
Diego Martinelli, Michela Catteruccia, Fiorella Piemonte, Anna Pastore, Giulia Tozzi, Martin Thoolen

Mol Genet Metab· November 2012

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Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy.
Alfredo A Sadun, Carlos Filipe Chicani, Fred N Ross-Cisneros, Piero Barboni, Martin Thoolen

Arch Neurol· March 2012

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Initial experience in the treatment of inherited mitochondrial disease with EPI-743.
Gregory M Enns, Stephen L Kinsman, Susan L Perlman, Kenneth M Spicer, Jose E Abdenur, Martin Thoolen

Mol Genet Metab· January 2012

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α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
William D Shrader, Akiko Amagata, Adam Barnes, Gregory M Enns, Andrew Hinman, Martin Thoolen

Bioorg Med Chem Lett· June 2011

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