Publications by authors named "Masato Nakashima"

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Biodistribution of AAV1, AAV5, AAV9, and AAVDJ serotypes after intra-cisterna magna delivery in non-human primates.
Takuro Okai, Sho Sato, Hironobu Yasuno, Miyu Nakayama, Syunsuke Yamamoto, Masato Nakashima

Mol Ther Methods Clin Dev· December 2025

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Characterization of a humanized mouse model of Charcot-Marie-Tooth type 1A for the discovery of human -targeting drugs.
Atsuki Taruta, Shin-Ichi Matsumoto, Yasushi Masuda, Tetsuaki Hiyoshi, Akina Harada, Masato Nakashima

Front Neurol· November 2025

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Electrical impedance myography detects progressive pathological alterations in the hindlimb muscle of the PMP22-C3 mice, an animal model of CMT1A.
Atsuki Taruta, Tetsuaki Hiyoshi, Akina Harada, Masato Nakashima

Exp Neurol· March 2025

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Practicality of multilayer round window reinforcement in the surgical management of superior semicircular canal dehiscence syndrome: a case report of long-term follow-up.
Masafumi Sawada, Han Matsuda, Yasuhiko Tanzawa, Kei Sakamoto, Hiroe Kudo, Masato Nakashima

Front Neurol· June 2024

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Electrical impedance myography detects dystrophin-related muscle changes in mdx mice.
Tetsuaki Hiyoshi, Fuqiang Zhao, Rina Baba, Takeshi Hirakawa, Ryosuke Kuboki, Masato Nakashima

Skelet Muscle· November 2023

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Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals.
Rebecca Evans, Haruhide Kimura, Masato Nakashima, Takashi Ishikawa, Hiroshi Yukitake

J Sleep Res· October 2023

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Urine titin as a novel biomarker for Duchenne muscular dystrophy.
Misawa Niki Ishii, Masato Nakashima, Hidenori Kamiguchi, Neta Zach, Ryosuke Kuboki

Neuromuscul Disord· April 2023

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Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
Yasutaka Hoashi, Takafumi Takai, Yohei Kosugi, Masato Nakashima, Masaharu Nakayama

J Med Chem· March 2021

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TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.
Masato Nakashima, Noriko Suzuki, Eri Shiraishi, Hiroki Iwashita

Behav Brain Res· December 2019

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TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
Emi Kurimoto, Masato Nakashima, Haruhide Kimura, Motohisa Suzuki

PLoS One· November 2019

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Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in -Methyl-d-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia.
Masato Nakashima, Haruka Imada, Eri Shiraishi, Yuki Ito, Noriko Suzuki

J Pharmacol Exp Ther· April 2018

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Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Satoshi Mikami, Masanori Kawasaki, Shuhei Ikeda, Nobuyuki Negoro, Shinji Nakamura, Masato Nakashima

Chem Pharm Bull (Tokyo)· November 2017

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Autophosphorylation of Specific Threonine and Tyrosine Residues in Arabidopsis CERK1 is Essential for the Activation of Chitin-Induced Immune Signaling.
Maruya Suzuki, Masatoshi Shibuya, Hikaru Shimada, Noriko Motoyama, Masato Nakashima

Plant Cell Physiol· November 2016

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Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons.
Koji Takeuchi, Masanori Takeeda, Kikuko Amagase, Masato Nakashima

Curr Pharm Des· March 2016

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Selective regulation of the chitin-induced defense response by the Arabidopsis receptor-like cytoplasmic kinase PBL27.
Tomonori Shinya, Koji Yamaguchi, Yoshitake Desaki, Kenta Yamada, Tomoko Narisawa, Masato Nakashima

Plant J· July 2014

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Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists.
Tatsuhiko Fujimoto, Jun Kunitomo, Yoshihide Tomata, Keiji Nishiyama, Masato Nakashima

Bioorg Med Chem Lett· November 2011

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Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.
Tatsuki Koike, Takafumi Takai, Yasutaka Hoashi, Masaharu Nakayama, Yohei Kosugi, Masato Nakashima

J Med Chem· June 2011

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[IgG4-related Mikulicz's disease: a report of 3 cases].
Hiroto Nakada, Osamu Shibasaki, Masato Nakashima, Hiroyoshi Yoshinami, Yasuhiro Kase

Nihon Jibiinkoka Gakkai Kaiho· October 2010

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A case of nasal natural killer/T lymphoma revealed by repeated deep neck abscess.
Shintaro Baba, Miyuki Baba, Miho Hagisawa, Miwako Kimura, Masato Nakashima

Am J Otolaryngol· September 2009

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Primary laryngeal natural killer/T-cell lymphoma--report of a rare case.
Hiroko Monobe, Masato Nakashima, Kunihiko Tominaga

Head Neck· November 2008

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Peritonsillar abscess with parapharyngeal and retropharyngeal involvement: incidence and intraoral approach.
Hiroko Monobe, Sayaka Suzuki, Masato Nakashima, Hitoshi Tojima, Kimitaka Kaga

Acta Otolaryngol Suppl· December 2007

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Tonsillar cyst of the false vocal cord.
Miwako Kimura, Masato Nakashima, Takaharu Nito, Niro Tayama

Auris Nasus Larynx· March 2007

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No role for prostacyclin IP receptors in duodenal HCO3- secretion induced by mucosal acidification in mice--comparison with capsaicin-induced response.
Masato Nakashima, Masako Aoi, Eitaro Aihara, Koji Takeuchi

Digestion· November 2004

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Participation of prostaglandin E receptor EP4 subtype in duodenal bicarbonate secretion in rats.
Masako Aoi, Eitaro Aihara, Masato Nakashima, Koji Takeuchi

Am J Physiol Gastrointest Liver Physiol· July 2004

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Prostaglandin E receptor EP1 subtype but not prostacyclin IP receptor involved in mucosal blood flow response of mouse stomachs following barrier disruption.
Yusuke Komoike, Masato Nakashima, Akari Nakagiri, Koji Takeuchi

Digestion· January 2004

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