Publications by authors named "Tatsuki Koike"

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Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.
Yoshiteru Ito, Tomoaki Hasui, Eiji Kimura, Izumi Nomura, Hiromi Fukuda, Tatsuki Koike

Bioorg Med Chem· October 2025

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Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors.
Yoshiteru Ito, Eiji Kimura, Izumi Nomura, Etsurou Watanabe, Jason Yano, Tatsuki Koike

Bioorg Med Chem· July 2025

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An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions.
Takashi Ishikawa, Emi Kurimoto, Adam A Joyal, Tatsuki Koike, Haruhide Kimura

Curr Biol· May 2025

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Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection.
Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba, Shuhei Kosono

Angew Chem Int Ed Engl· February 2025

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TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models.
Kayo Mitsukawa, Michiko Terada, Ryuji Yamada, Taku Monjo, Tetsuaki Hiyoshi, Tatsuki Koike

Sci Rep· September 2024

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Effects of an OX2R agonist on migration and removal of tau from mouse brain.
Michiko Terada, Kayo Mitsukawa, Masanori Nakakariya, Tatsuki Koike, Haruhide Kimura

Sci Rep· July 2024

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Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons in rodents.
Ryuji Yamada, Tatsuki Koike, Masanori Nakakariya, Haruhide Kimura

PLoS One· June 2024

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TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.
Takashi Ishikawa, Hiroe Hara, Ayumi Kawano, Kimio Tohyama, Yuichi Kajita, Tatsuki Koike

J Pharmacol Exp Ther· June 2023

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Reply to: The G protein preference of orexin receptors is currently an unresolved issue.
Jie Yin, Yanyong Kang, Aaron P McGrath, Karen Chapman, Megan Sjodt, Tatsuki Koike

Nat Commun· June 2023

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Deep learning for hetero-homo conversion in channel-domain for phase aberration correction in ultrasound imaging.
Tatsuki Koike, Naoki Tomii, Yoshiki Watanabe, Takashi Azuma, Shu Takagi

Ultrasonics· March 2023

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Deep Learning-Based Seminal Vesicle and Vas Deferens Recognition in the Posterior Approach of Robot-Assisted Radical Prostatectomy.
Nobushige Takeshita, Shinichi Sakamoto, Daichi Kitaguchi, Nobuyoshi Takeshita, Shugo Yajima, Tatsuki Koike

Urology· March 2023

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Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).
Shuhei Ikeda, Yuichi Kajita, Maki Miyamoto, Kouta Matsumiya, Tsuyoshi Ishii, Tatsuki Koike

Eur J Med Chem· October 2022

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Molecular mechanism of the wake-promoting agent TAK-925.
Jie Yin, Yanyong Kang, Aaron P McGrath, Karen Chapman, Megan Sjodt, Tatsuki Koike

Nat Commun· May 2022

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Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [F]T-401 and PET.
Yasushi Hattori, Chie Seki, Jun Maeda, Yuji Nagai, Kazunobu Aoyama, Tatsuki Koike

J Cereb Blood Flow Metab· April 2022

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Preclinical characterization of [F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.
Tatsuki Koike, Cristian C Constantinescu, Shuhei Ikeda, Toshiya Nishi, Eiji Sunahara

Eur J Nucl Med Mol Imaging· March 2022

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Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
Yuichi Kajita, Shuhei Ikeda, Masato Yoshikawa, Hiromi Fukuda, Etsurou Watanabe, Tatsuki Koike

J Med Chem· February 2022

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Synthesis of low-molecular weight fucoidan derivatives and their binding abilities to SARS-CoV-2 spike proteins.
Tatsuki Koike, Aoi Sugimoto, Shuhei Kosono, Sumika Komaba, Yuko Kanno

RSC Med Chem· December 2021

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Design, Synthesis, and Evaluation of [F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1.
Satoru Matsuda, Yasushi Hattori, Kouta Matsumiya, Paul McQuade, Tohru Yamashita, Tatsuki Koike

J Med Chem· September 2021

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Design, Synthesis, and Evaluation of C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain.
Yasushi Hattori, Tomoteru Yamasaki, Tomohiro Ohashi, Yuhei Miyanohana, Tomokazu Kusumoto, Tatsuki Koike

J Med Chem· August 2021

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Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).
Tatsuki Koike, Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Toshiya Nishi

J Med Chem· August 2021

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Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain.
Yasushi Hattori, Satoru Matsuda, Rina Baba, Kouta Matsumiya, Shinji Iwasaki, Tatsuki Koike

J Med Chem· April 2021

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Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
Yasutaka Hoashi, Takafumi Takai, Yohei Kosugi, Masato Nakashima, Masaharu Nakayama, Tatsuki Koike

J Med Chem· March 2021

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Discovery of a Novel and Brain-Penetrant -GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
Michiko Tawada, Makoto Fushimi, Kei Masuda, Huikai Sun, Noriko Uchiyama, Tatsuki Koike

J Med Chem· January 2021

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Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.
Toshiya Nishi, Shinichi Kondo, Maki Miyamoto, Sayuri Watanabe, Shigeo Hasegawa, Tatsuki Koike

Sci Rep· October 2020

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Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.
Yasushi Hattori, Kazunobu Aoyama, Jun Maeda, Naoto Arimura, Yasuko Takahashi, Tatsuki Koike

J Med Chem· March 2019

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