Publications by authors named "Mathieu Magali"

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Structural determination of small proteins by cryo-EM using a coiled coil module strategy.
Samson Camille, Dossou Irène, Steinmetz Anke, Kumar Anand, Mathieu Magali

Sci Rep· October 2025

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Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex.
Rémi Ruedas, Rémi Vuillemot, Thibault Tubiana, Jean-Marie Winter, Laura Pieri, Magali Mathieu

J Struct Biol· June 2024

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Structural insights into the bi-specific cross-over dual variable antibody architecture by cryo-EM.
David Fernandez-Martinez, Mark D Tully, Gordon Leonard, Magali Mathieu, Eaazhisai Kandiah

Sci Rep· May 2023

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Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold.
Tiphanie Pruvost, Magali Mathieu, Steven Dubois, Bernard Maillère, Emmanuelle Vigne

MAbs· February 2023

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An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics.
Norbert Furtmann, Marion Schneider, Nadja Spindler, Bjoern Steinmann, Ziyu Li, Magali Mathieu

MAbs· January 2022

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KRAS G12C fragment screening renders new binding pockets.
Magali Mathieu, Valérie Steier, Florence Fassy, Cécile Delorme, David Papin

Small GTPases· January 2022

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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
Youssef El-Ahmad, Michel Tabart, Frank Halley, Victor Certal, Fabienne Thompson, Magali Mathieu

J Med Chem· January 2020

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Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor.
Claudio Dalvit, Annick Parent, Francois Vallée, Magali Mathieu, Alexey Rak

ChemMedChem· June 2019

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Differential Water Thermodynamics Determine PI3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications.
Daniel Robinson, Thomas Bertrand, Jean-Christophe Carry, Frank Halley, Andreas Karlsson, Magali Mathieu

J Chem Inf Model· May 2016

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Automated harvesting and processing of protein crystals through laser photoablation.
Ulrich Zander, Guillaume Hoffmann, Irina Cornaciu, Jean-Pierre Marquette, Gergely Papp, Magali Mathieu

Acta Crystallogr D Struct Biol· April 2016

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Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.
Gejing Deng, Junqing Shen, Ming Yin, Jessica McManus, Magali Mathieu

J Biol Chem· January 2015

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Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Magali Mathieu

J Med Chem· January 2015

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Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions.
Aaron Moulin, Magali Mathieu, Catherine Lawrence, Russell Bigelow, Mark Levine

Protein Sci· December 2014

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A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
Baptiste Ronan, Odile Flamand, Lionel Vescovi, Christine Dureuil, Laurence Durand, Magali Mathieu

Nat Chem Biol· December 2014

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Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
Victor Certal, Jean-Christophe Carry, Frank Halley, Angela Virone-Oddos, Fabienne Thompson, Magali Mathieu

J Med Chem· February 2014

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Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent.
Guyan Liang, Suzanne Aldous, Gregory Merriman, Julian Levell, James Pribish, Magali Mathieu

Bioorg Med Chem Lett· January 2012

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Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.
Stefanie Keil, Hans Matter, Karl Schönafinger, Maike Glien, Magali Mathieu

ChemMedChem· April 2011

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Molecular shape and medicinal chemistry: a perspective.
Anthony Nicholls, Georgia B McGaughey, Robert P Sheridan, Andrew C Good, Gregory Warren, Magali Mathieu

J Med Chem· May 2010

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Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.
Corey R Hopkins, Mark Czekaj, Steven S Kaye, Zhongli Gao, James Pribish, Magali Mathieu

Bioorg Med Chem Lett· June 2005

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Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy.
Magali Mathieu, Guy Debousker, Sophie Vincent, Fabrice Viviani, Nathalie Bamas-Jacques

J Biol Chem· May 2005

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Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase.
Sharon A Jackson, Sukhveen Sahni, Lan Lee, Yongyi Luo, Thaddeus R Nieduzak, Magali Mathieu

Bioorg Med Chem· April 2005

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Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.
Corey Hopkins, Kent Neuenschwander, Anthony Scotese, Sharon Jackson, Thaddeus Nieduzak, Magali Mathieu

Bioorg Med Chem Lett· October 2004

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The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
Jean-Pierre Guilloteau, Magali Mathieu, Carmela Giglione, Véronique Blanc, Alain Dupuy

J Mol Biol· July 2002

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