Publications by authors named "Matt Hrapchak"

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Synthesis of Carbon 14 and Deuterium-Labelled Nerandomilast (BI 1015550).
Bachir Latli, Matt J Hrapchak, Rogelio P Frutos

J Labelled Comp Radiopharm· May 2025

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A Radioactivity-mass Spectrometry Calibration Method Coupled with Biosynthesis to Generate a Metabolite Standard for Enzyme Kinetics Studies.
Ting Wang, Cody Thomas, Bachir Latli, Matt Hrapchak, Mitchell E Taub

J Pharm Sci· September 2024

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Carbon 14 and Carbon 13 Syntheses of Velagliflozin.
Bachir Latli, Matt J Hrapchak, Maxim Chevliakov, Chutian Shu

J Labelled Comp Radiopharm· May 2024

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Stable isotope synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites.
Bachir Latli, Matt J Hrapchak, Maxim Chevliakov, Lalith P Samankumara, Rogelio P Frutos

J Labelled Comp Radiopharm· November 2023

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Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites.
Bachir Latli, Matt J Hrapchak, Rogelio P Frutos, Heewon Lee, Jinhua J Song

J Labelled Comp Radiopharm· September 2023

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Carbon 14 and stable isotope synthesis of two potent and selective phosphodiesterase type 4 inhibitors.
Bachir Latli, Matt J Hrapchak, Thomas G Tampone, Rogelio P Frutos, Heewon Lee

J Labelled Comp Radiopharm· September 2023

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Synthesis of beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors BI 1147560 and BI 1181181 labeled with carbon-14 and deuterium.
Bachir Latli, Matt J Hrapchak, Jonathan T Reeves, Heewon Lee, Jinhua J Song

J Labelled Comp Radiopharm· May 2023

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Synthesis of BI 894416 and BI 1342561, two potent and selective spleen tyrosine kinase inhibitors, labeled with carbon 14 and with deuterium.
Bachir Latli, Matt J Hrapchak, Lalith P Samankumara, Daniel R Fandrick, Scott Pennino

J Labelled Comp Radiopharm· May 2023

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Synthesis of highly potent lymphocyte function-associated antigen-1 antagonists labeled with carbon-14 and with stable isotopes, part 3.
Bachir Latli, Matt Hrapchak, Guisheng Li, Jon Lorenz, Josh Horan

J Labelled Comp Radiopharm· February 2019

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Potent and selective CC chemokine receptor 1 antagonists labeled with carbon-13, carbon-14, and tritium.
Bachir Latli, Matt Hrapchak, Maxim Cheveliakov, Jonathan T Reeves, Maurice Marsini

J Labelled Comp Radiopharm· May 2018

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Corrigendum: Potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 labeled with carbon-13 and carbon-14.
Bachir Latli, Matt Hrapchak, Jolaine Savoie, Yongda Zhang, Carl A Busacca

J Labelled Comp Radiopharm· February 2018

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Potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 labeled with carbon-13 and carbon-14.
Bachir Latli, Matt Hrapchak, Jolaine Savoie, Yongda Zhang, Carl A Busacca

J Labelled Comp Radiopharm· July 2017

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Carbon-13 and carbon-14 labeled dabigatran etexilate and tritium labeled dabigatran.
Bachir Latli, Ralf Kiesling, Stefan Aßfalg, Max Chevliakov, Matt Hrapchak

J Labelled Comp Radiopharm· December 2016

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Buscopan labeled with carbon-14 and deuterium.
Bachir Latli, Michael Stiasni, Matt Hrapchak, Zhibin Li, Nelu Grinberg

J Labelled Comp Radiopharm· November 2016

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Synthesis of two potent glucocorticoid receptor agonists labeled with carbon-14 and stable isotopes.
Bachir Latli, Jonathan T Reeves, Zhulin Tan, Matt Hrapchak, Jinhua J Song

J Labelled Comp Radiopharm· August 2016

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A potent IκB kinase-β inhibitor labeled with carbon-14 and deuterium.
Bachir Latli, Magnus Eriksson, Matt Hrapchak, Carl A Busacca, Chris H Senanayake

J Labelled Comp Radiopharm· June 2016

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A novel five-lipoxygenase activity protein inhibitor labeled with carbon-14 and deuterium.
Bachir Latli, Matt Hrapchak, Joe J Gao, Carl A Busacca, Chris H Senanayake

J Labelled Comp Radiopharm· July 2015

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Synthesis of deleobuvir, a potent hepatitis C virus polymerase inhibitor, and its major metabolites labeled with carbon-13 and carbon-14.
Bachir Latli, Matt Hrapchak, Maxim Chevliakov, Guisheng Li, Scot Campbell

J Labelled Comp Radiopharm· May 2015

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Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13.
Matt Hrapchak, Bachir Latli, Xiao-Jun Wang, Heewon Lee, Scot Campbell

J Labelled Comp Radiopharm· October 2014

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Hepatitis C virus serine protease: synthesis of radioactive and stable isotope-labeled potent inhibitors.
Bachir Latli, Matt Hrapchak, Vida Gorys, Montse Llinàs-Brunet, Scot S Campbell

J Labelled Comp Radiopharm· May 2014

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Sodium-proton exchanger isoform-1: synthesis of a potent inhibitor labeled with deuterium and carbon-14.
Bachir Latli, Nizar Haddad, Matt Hrapchak, Xudong Wei, Wenjun Tang

Curr Radiopharm· March 2013

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Synthesis of a potent cathepsin s inhibitor labeled with deuterium and carbon-14.
Bachir Latli, Matt Hrapchak, Jon C Lorenz, Carl A Busacca, Chris Senanayake

Curr Radiopharm· October 2012

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The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Jiang-Ping Wu, Roman Fleck, Janice Brickwood, Alison Capolino, Katrina Catron, Matt Hrapchak

Bioorg Med Chem Lett· October 2009

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Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Tina Morwick, Angela Berry, Janice Brickwood, Mario Cardozo, Katrina Catron, Matt Hrapchak

J Med Chem· May 2006

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A superior method for the reduction of secondary phosphine oxides.
Carl A Busacca, Jon C Lorenz, Nelu Grinberg, Nizar Haddad, Matt Hrapchak

Org Lett· September 2005

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