Publications by authors named "Matteo Biagetti"

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Discovery of CHF-6523, an Inhaled Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.
Paolo Bruno, Daniele Pala, Alessandra Micoli, Mauro Corsi, Alessandro Accetta, Matteo Biagetti

J Med Chem· February 2025

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Transition Metal-Driven Selectivity in Direct C-H Arylation of Imidazo[2,1-b]Thiazole.
Antonio Del Vecchio, Elisabetta Rosadoni, Lorenzo Ballerini, Angela Cuzzola, Filippo Lipparini, Matteo Biagetti

ChemistryOpen· November 2024

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Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors.
Daniele Pala, Paolo Ronchi, Donatella Rescigno, Barbara Bertani, Anna Maria Capelli, Matteo Biagetti

ACS Med Chem Lett· November 2024

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Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation.
Paolo Bruno, Alessandra Micoli, Mauro Corsi, Daniele Pala, Sara Guariento, Matteo Biagetti

J Med Chem· July 2024

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Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors.
Roberta Mazzucato, Marinella Roberti, Anna Maria Capelli, Fabio Rancati, Matteo Biagetti

Eur J Med Chem· June 2023

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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Laura Carzaniga, Ian D Linney, Andrea Rizzi, Maurizio Delcanale, Wolfgang Schmidt, Matteo Biagetti

J Med Chem· August 2022

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Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives.
Fabio Bellina, Matteo Biagetti, Sara Guariento, Marco Lessi, Mattia Fausti

RSC Adv· July 2021

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Non-regioselective functionalization: an underestimate chemical diversity generator in medicinal chemistry.
Sara Guariento, Matteo Biagetti, Paolo Ronchi

Future Med Chem· April 2021

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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.
Alessio Lodola, Serena Bertolini, Matteo Biagetti, Silvia Capacchi, Fabrizio Facchinetti

J Med Chem· May 2017

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Gene expression and biochemical changes of carbohydrate metabolism in in vitro micro-propagated apple plantlets infected by 'Candidatus Phytoplasma mali'.
Filomena Giorno, Gea Guerriero, Matteo Biagetti, Anna Maria Ciccotti, Sanja Baric

Plant Physiol Biochem· September 2013

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Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists.
Domenica Antonia Pizzi, Colin Philip Leslie, Angelica Mazzali, Catia Seri, Matteo Biagetti

Bioorg Med Chem Lett· December 2010

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Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.
Colin P Leslie, Matteo Biagetti, Silvia Bison, Steven M Bromidge, Romano Di Fabio

J Med Chem· December 2010

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The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.
Gillian E Lunniss, Ashley A Barnes, Nick Barton, Matteo Biagetti, Federica Bianchi

Bioorg Med Chem Lett· December 2010

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Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists.
Colin P Leslie, Jonathan Bentley, Matteo Biagetti, Stefania Contini, Romano Di Fabio

Bioorg Med Chem Lett· October 2010

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Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.
Matteo Biagetti, Colin Philip Leslie, Angelica Mazzali, Catia Seri, Domenica Antonia Pizzi

Bioorg Med Chem Lett· August 2010

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The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.
Gillian E Lunniss, Ashley A Barnes, Nick Barton, Matteo Biagetti, Federica Bianchi

Bioorg Med Chem Lett· August 2009

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