Publications by authors named "Matthew B Frieman"

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The mammalian SKI complex is a broad-spectrum antiviral drug target that upregulates cellular cholesterol to inhibit viral replication.
Stuart Weston, Lauren Baracco, Louis Taylor, Alison J Scott, Gaurav Kumar, Matthew B Frieman

J Virol· October 2025

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Discovery, phylogenetic, and comparative genomic analysis of novel avian gammacoronaviruses identified in feral pigeons ().
Mohamed E El Zowalaty, Louis J Taylor, Yongwoo Son, Heesu Lee, Adam M Rubrum, Matthew B Frieman

J Virol· September 2025

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Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.
Xin Yin, Yuan Pu, Shuofeng Yuan, Lars Pache, Christopher Churas, Matthew B Frieman

PLoS Biol· June 2025

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Placental SARS-CoV-2 Infection and Its Implications for Increased Risk of Adverse Pregnancy Outcomes.
Bingbing Wang, Wei-Bin Shen, Karl E Seif, Courtney Townsel, Lauren Baracco, Matthew B Frieman

Am J Perinatol· January 2025

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Corrigendum: Placental SARS-CoV-2 Infection and Its Implications for Increased Risk of Adverse Pregnancy Outcomes.
Bingbing Wang, Wei-Bin Shen, Karl E Seif, Courtney Townsel, Lauren Baracco, Matthew B Frieman

Am J Perinatol· January 2025

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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice.
James Brett Case, Shilpa Sanapala, Carly Dillen, Victoria Rhodes, Christian Zmasek, Matthew B Frieman

Cell Host Microbe· December 2024

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The BNT162b2 mRNA vaccine demonstrates reduced age-associated T1 support and .
Byron Brook, Abhinav Kumar Checkervarty, Soumik Barman, Cali Sweitzer, Anna-Nicole Bosco, Matthew B Frieman

iScience· November 2024

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Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice.
Aaron F Carlin, James R Beadle, Jeremy Ardanuy, Alex E Clark, Victoria Rhodes, Matthew B Frieman

Antimicrob Agents Chemother· October 2024

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Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle Replication.
Xin Yin, Yuan Pu, Shuofeng Yuan, Lars Pache, Christopher Churas, Matthew B Frieman

bioRxiv· July 2024

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SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.
Marisa E McGrath, Yong Xue, Louis Taylor, Carly Dillen, Jeremy Ardanuy, Matthew B Frieman

PLoS Pathog· May 2024

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CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication and .
James Logue, Victoria M Melville, Jeremy Ardanuy, Matthew B Frieman

bioRxiv· December 2023

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CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo.
James Logue, Victoria M Melville, Jeremy Ardanuy, Matthew B Frieman

PLoS Pathog· December 2023

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Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
Timothy R O'Meara, Etsuro Nanishi, Marisa E McGrath, Soumik Barman, Danica Dong, Matthew B Frieman

J Allergy Clin Immunol· November 2023

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Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.
Sara Sunshine, Andreas S Puschnik, Joseph M Replogle, Matthew T Laurie, Jamin Liu, Matthew B Frieman

Nat Commun· October 2023

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SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection.
Minghua Li, Kasirajan Ayyanathan, Mark Dittmar, Jesse Miller, Iulia Tapescu, Matthew B Frieman

mBio· August 2023

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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8.
Bruno A Rodriguez-Rodriguez, Grace O Ciabattoni, Ralf Duerr, Ana M Valero-Jimenez, Stephen T Yeung, Matthew B Frieman

Nat Commun· May 2023

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Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
Xiaoquan Rao, Michael Razavi, Georgeta Mihai, Yingying Wei, Zachary Braunstein, Matthew B Frieman

Adv Sci (Weinh)· March 2023

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Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.
Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R O'Meara, Marisa E McGrath, Matthew B Frieman

NPJ Vaccines· March 2023

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Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.
Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R O'Meara, Marisa E McGrath, Matthew B Frieman

NPJ Vaccines· February 2023

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Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants.
James Logue, Robert M Johnson, Nita Patel, Bin Zhou, Sonia Maciejewski, Matthew B Frieman

Nat Commun· February 2023

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Enhancing the protection of influenza virus vaccines with BECC TLR4 adjuvant in aged mice.
Robert Haupt, Lauren Baracco, Erin M Harberts, Madhumathi Loganathan, Lucas J Kerstetter, Matthew B Frieman

Sci Rep· January 2023

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Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection.
Mohammad M Sajadi, Amber Myers, James Logue, Saman Saadat, Narjes Shokatpour, Matthew B Frieman

mSphere· December 2022

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Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
Timothy R O'Meara, Etsuro Nanishi, Marisa E McGrath, Soumik Barman, Danica Dong, Matthew B Frieman

bioRxiv· December 2022

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The mRNA vaccine BNT162b2 demonstrates impaired T1 immunogenicity in human elders and aged mice .
Byron Brook, Benoit Fatou, Abhinav Kumar Checkervarty, Soumik Barman, Cali Sweitzer, Matthew B Frieman

Res Sq· December 2022

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SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis.
Marisa E McGrath, Yong Xue, Carly Dillen, Lauren Oldfield, N Assad-Garcia, Matthew B Frieman

Proc Natl Acad Sci U S A· September 2022

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