Publications by authors named "Matthew D Disney"

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Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for mRNA Degradation.
Xiaoxuan Su, Yuquan Tong, Patrick R A Zanon, Jielei Wang, Toru Tanaka, Jessica L Childs-Disney, Matthew D Disney

J Am Chem Soc· December 2025

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Chemical Tagging of -Alkylamine-Containing Natural Products and Pharmaceuticals through C()-H Functionalization.
Yuankai Wang, Cunyuan Zhao, Tenghui Wang, Andrew Steele, Manas Joshi, Matthew D Disney

J Am Chem Soc· November 2025

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Live-Cell Covalent Profiling Reveals Principles of RNA-Small Molecule Recognition across the Human Transcriptome.
Yuquan Tong, Amirhossein Taghavi, Xiaoxuan Su, Xueyi Yang, Warren Rouse, Jessica L Childs-Disney, Matthew D Disney

bioRxiv· November 2025

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RNA-Focused DNA-Encoded Library Construction, Screening, and Integration of Docking Identify Bioactive Ligands of Pathogenic r(GC) RNA.
Xueyi Yang, Amirhossein Taghavi, Yoshihiro Akahori, Martina Pedrini, Takahiro Ishii, Matthew D Disney

bioRxiv· November 2025

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A Live-Cell NanoBRET Assay to Monitor RNA-Protein Interactions and Their Inhibition by Small Molecules.
Jingsong Shan, Amirhossein Taghavi, Elizabeth A Caine, Ryuichi Sekioka, Veronika Rajchin, Jessica L Childs-Disney, Matthew D Disney

ACS Cent Sci· November 2025

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eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis.
Nancy G Casanova, Jose D Herazo-Maya, Carrie L Kempf, Belinda L Sun, Jin H Song, Matthew D Disney

Am J Respir Cell Mol Biol· October 2025

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Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design.
Sandra Kovachka, Jielei Wang, Amirhossein Taghavi, Yilin Jia, Taro Asaba, Jessica L Childs-Disney, Matthew D Disney

J Am Chem Soc· October 2025

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Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch.
Chungen Li, Xueyi Yang, Kyle A Dickerson, Patrick R A Zanon, Noah A Springer, Matthew D Disney

J Am Chem Soc· October 2025

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Streamlined Fragment-Based Discovery Platform for Targeting Structured RNAs.
Yilin Jia, Amirhossein Taghavi, Patrick R A Zanon, Matthew D Disney

ACS Chem Biol· September 2025

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Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders.
Noah A Springer, Patrick R A Zanon, Amirhossein Taghavi, Kisu Sung, Matthew D Disney

J Am Chem Soc· September 2025

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Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch.
Chungen Li, Xueyi Yang, Kyle A Dickerson, Patrick R A Zanon, Noah A Springer, Matthew D Disney

bioRxiv· August 2025

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Design of an Orally Bioavailable Small Molecule That Modulates the Microtubule-Associated Protein Tau's Pre-mRNA Splicing.
Peiyuan Zhang, Amirhossein Taghavi, Masahito Abe, Haruo Aikawa, Yoshihiro Akahori, Jessica L Childs-Disney, Matthew D Disney

ACS Chem Biol· July 2025

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Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models.
Samantha M Meyer, Sandra Kovachka, Tenghui Wang, Michael D Cameron, Jessica L Childs-Disney, Matthew D Disney

J Med Chem· June 2025

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The evolution and application of RNA-focused small molecule libraries.
Amirhossein Taghavi, Noah A Springer, Patrick R A Zanon, Yanjun Li, Chenglong Li, Jessica L Childs-Disney, Matthew D Disney

RSC Chem Biol· April 2025

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The Druggable Transcriptome Project: From Chemical Probes to Precision Medicines.
Matthew D Disney

Biochemistry· April 2025

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Mapping small molecule-RNA binding sites via Chem-CLIP synergized with capillary electrophoresis and nanopore sequencing.
Xueyi Yang, Jielei Wang, Noah A Springer, Patrick R A Zanon, Yilin Jia, Matthew D Disney

Nucleic Acids Res· March 2025

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Sustained Epigenetic Reactivation in Fragile X Neurons with an RNA-Binding Small Molecule.
Christina W Kam, Jason G Dumelie, Gabriele Ciceri, Wang-Yong Yang, Matthew D Disney

Genes (Basel)· February 2025

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Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes.
Kathryn R Bowles, Chiara Pedicone, Derian A Pugh, Laura-Maria Oja, Filipa H Sousa, Matthew D Disney

Cell Rep· December 2024

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Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40.
Yuquan Tong, Jessica L Childs-Disney, Matthew D Disney

Br J Pharmacol· November 2024

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NMR structures of small molecules bound to a model of a CUG RNA repeat expansion.
Jonathan L Chen, Amirhossein Taghavi, Alexander J Frank, Matthew A Fountain, Shruti Choudhary, Jessica L Childs-Disney, Matthew D Disney

Bioorg Med Chem Lett· October 2024

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Protocol for transcriptome-wide mapping of small-molecule RNA-binding sites in live cells.
Yuquan Tong, Patrick R A Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L Childs-Disney, Matthew D Disney

STAR Protoc· September 2024

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Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras.
Yuquan Tong, Xiaoxuan Su, Warren Rouse, Jessica L Childs-Disney, Amirhossein Taghavi, Matthew D Disney

J Am Chem Soc· August 2024

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NMR structures and magnetic force spectroscopy studies of small molecules binding to models of an RNA CAG repeat expansion.
Amirhossein Taghavi, Jonathan L Chen, Zhen Wang, Krishshanthi Sinnadurai, David Salthouse, Jessica L Childs-Disney, Matthew D Disney

bioRxiv· August 2024

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Transcriptome-wide mapping of small-molecule RNA-binding sites in live cells.
Yuquan Tong, Patrick R A Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L Childs-Disney, Matthew D Disney

bioRxiv· June 2024

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NMR structures of small molecules bound to a model of an RNA CUG repeat expansion.
Jonathan L Chen, Amirhossein Taghavi, Alexander J Frank, Matthew A Fountain, Shruti Choudhary, Jessica L Childs-Disney, Matthew D Disney

bioRxiv· June 2024

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