Publications by authors named "Matthew D Figley"

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The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems.
Aaron DiAntonio, Jeffrey Milbrandt, Matthew D Figley

Front Immunol· February 2022

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Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
Tong Wu, Jian Zhu, Amy Strickland, Kwang Woo Ko, Yo Sasaki, Matthew D Figley

Cell Rep· October 2021

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SARM1 is a metabolic sensor activated by an increased NMN/NAD ratio to trigger axon degeneration.
Matthew D Figley, Weixi Gu, Jeffrey D Nanson, Yun Shi, Yo Sasaki

Neuron· April 2021

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Multiple domain interfaces mediate SARM1 autoinhibition.
Chen Shen, Mihir Vohra, Pengfei Zhang, Xianrong Mao, Matthew D Figley

Proc Natl Acad Sci U S A· January 2021

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The SARM1 axon degeneration pathway: control of the NAD metabolome regulates axon survival in health and disease.
Matthew D Figley, Aaron DiAntonio

Curr Opin Neurobiol· August 2020

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cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.
Yo Sasaki, Thomas M Engber, Robert O Hughes, Matthew D Figley, Tong Wu

Exp Neurol· July 2020

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Neurodegeneration: A Leg Up on TDP-43.
Matthew D Figley, Aaron D Gitler

Curr Biol· August 2015

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Yeast genetic screen reveals novel therapeutic strategy for ALS.
Matthew D Figley, Aaron D Gitler

Rare Dis· July 2014

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Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.
Matthew D Figley, Gregor Bieri, Regina-Maria Kolaitis, J Paul Taylor, Aaron D Gitler

J Neurosci· June 2014

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Evaluating noncoding nucleotide repeat expansions in amyotrophic lateral sclerosis.
Matthew D Figley, Anna Thomas, Aaron D Gitler

Neurobiol Aging· April 2014

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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
Maria Armakola, Matthew J Higgins, Matthew D Figley, Sami J Barmada, Emily A Scarborough

Nat Genet· December 2012

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