Publications by authors named "Matthew D Helm"

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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.
Anamarija Jurisic, Pei-Ju Sung, Mark Wappett, Julien Daubriac, Ian T Lobb, Matthew D Helm

Clin Transl Med· April 2024

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Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
Colin R O'Dowd, Matthew D Helm, J S Shane Rountree, Jakub T Flasz, Elias Arkoudis

ACS Med Chem Lett· March 2018

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Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
Gerald Gavory, Colin R O'Dowd, Matthew D Helm, Jakub Flasz, Elias Arkoudis

Nat Chem Biol· February 2018

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Total synthesis of (+)-pleuromutilin.
Neal J Fazakerley, Matthew D Helm, David J Procter

Chemistry· May 2013

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Mechanistic studies into amine-mediated electrophilic arene borylation and its application in MIDA boronate synthesis.
Viktor Bagutski, Alessandro Del Grosso, Josue Ayuso Carrillo, Ian A Cade, Matthew D Helm

J Am Chem Soc· January 2013

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Simple inexpensive boron electrophiles for direct arene borylation.
Alessandro Del Grosso, Matthew D Helm, Sophia A Solomon, Dolores Caras-Quintero, Michael J Ingleson

Chem Commun (Camb)· December 2011

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A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin.
Thomas J K Findley, David Sucunza, Laura C Miller, Matthew D Helm, Madeleine Helliwell

Org Biomol Chem· April 2011

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A dialdehyde cyclization cascade: an approach to pleuromutilin.
Matthew D Helm, Madeleine Da Silva, David Sucunza, Thomas J K Findley, David J Procter

Angew Chem Int Ed Engl· February 2010

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Preparation of silyl substituted crotylzinc reagents and their highly diastereoselective addition to carbonyl compounds.
Matthew D Helm, Peter Mayer, Paul Knochel

Chem Commun (Camb)· April 2008

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A sydnone cycloaddition route to pyrazole boronic esters.
Duncan L Browne, Matthew D Helm, Andrew Plant, Joseph P A Harrity

Angew Chem Int Ed Engl· January 2008

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The participation of alkynylboronates in inverse electron demand [4 + 2] cycloadditions: a mechanistic study.
Enrique Gomez-Bengoa, Matthew D Helm, Andrew Plant, Joseph P A Harrity

J Am Chem Soc· March 2007

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A novel approach to functionalised pyridazinone arrays.
Matthew D Helm, Andrew Plant, Joseph P A Harrity

Org Biomol Chem· December 2006

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Synthesis of highly substituted pyridazines through alkynyl boronic ester cycloaddition reactions.
Matthew D Helm, Jane E Moore, Andrew Plant, Joseph P A Harrity

Angew Chem Int Ed Engl· June 2005

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