Publications by authors named "Matthew Locke"

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Next-generation FVIIIa-mimetic bispecific antibody NXT007: evaluation in preclinical models of hemostasis and thrombosis.
Matthew Locke, Jamie Albiez, Nicolas Receveur, Sandra Marbach, Nina Frey

Blood Adv· November 2025

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A pathway toward clinical translation of hyperpolarized [1,4-C,2,3-d]fumarate as an imaging biomarker for early cellular necrosis in vivo.
Jonathan R Birchall, Pascal Wodtke, Ashley Grimmer, Esben S S Hansen, Lotte B Bertelsen, Matthew J Locke

Magn Reson Med· September 2025

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Assessment of early response to neoadjuvant chemotherapy in multi-site high-grade serous ovarian cancer using hyperpolarized-C MRI.
Lucian Beer, Vlad Bura, Stephan Ursprung, Ramona Woitek, Mary A McLean, Matthew Locke

EJNMMI Res· April 2025

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Measuring cerebral enzymatic activity, brain pH and extracranial muscle metabolism with hyperpolarized C-pyruvate.
Alixander S Khan, Mary A McLean, Joshua D Kaggie, Ines Horvat-Menih, Tomasz Matys, Matthew J Locke

NMR Biomed· December 2024

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Multiarm, non-randomised, single-centre feasibility study-investigation of the differential biology between benign and malignant renal masses using advanced magnetic resonance imaging techniques (IBM-Renal): protocol.
Ines Horvat-Menih, Mary A McLean, Maria Jesus Zamora-Morales, Marta Wylot, Joshua Kaggie, Matthew J Locke

BMJ Open· October 2024

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Deuterium metabolic imaging and hyperpolarized C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism.
Joshua D Kaggie, Alixander S Khan, Tomasz Matys, Rolf F Schulte, Matthew J Locke

Neuroimage· August 2022

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Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study.
Fulvio Zaccagna, Mary A McLean, James T Grist, Joshua Kaggie, Richard Mair, Matthew Locke

Radiol Imaging Cancer· July 2022

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Author Correction: Hyperpolarised C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
Nikita Sushentsev, Mary A McLean, Anne Y Warren, Arnold J V Benjamin, Cara Brodie, Matthew J Locke

Nat Commun· March 2022

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Hyperpolarized C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.
Stephan Ursprung, Ramona Woitek, Mary A McLean, Andrew N Priest, Mireia Crispin-Ortuzar, Matthew J Locke

Cancers (Basel)· January 2022

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Hyperpolarised C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
Nikita Sushentsev, Mary A McLean, Anne Y Warren, Arnold J V Benjamin, Cara Brodie, Matthew J Locke

Nat Commun· January 2022

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Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients.
Ramona Woitek, Mary A McLean, Stephan Ursprung, Oscar M Rueda, Raquel Manzano Garcia, Matthew J Locke

Cancer Res· December 2021

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Extracellular Histones Inhibit Fibrinolysis through Noncovalent and Covalent Interactions with Fibrin.
Matthew Locke, Colin Longstaff

Thromb Haemost· April 2021

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An international collaborative study to establish the WHO 3rd International Standard for Thrombin: Communication from the ISTH SSC subcommittee on factor XIII and fibrinogen.
Matthew Locke, Colin Longstaff, Peter Rigsby

J Thromb Haemost· March 2021

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Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin.
Matthew Locke, Robert J Francis, Evgenia Tsaousi, Colin Longstaff

Sci Rep· July 2020

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Hyperpolarized C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer.
Ramona Woitek, Mary A McLean, Andrew B Gill, James T Grist, Elena Provenzano, Matthew Locke

Radiol Imaging Cancer· July 2020

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An international collaborative study to establish the WHO 4th International Standard for Streptokinase: Communication from the SSC of the ISTH.
Matthew Locke, Peter Rigsby, Colin Longstaff,

J Thromb Haemost· June 2020

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How treatment delay may lead to loss of effectiveness of tranexamic acid.
Matthew Locke, Colin Longstaff

ANZ J Surg· April 2020

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Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A Gallagher, Ramona Woitek, Mary A McLean, Andrew B Gill, Raquel Manzano Garcia, Matthew Locke

Proc Natl Acad Sci U S A· January 2020

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Maintaining peri-implant health: an evaluation of understanding among dental hygienists and therapists in Wales.
Jann Siew Chin, Jeremy Rees, Matthew Locke, Liam D Addy

Br Dent J· June 2019

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Teaching of implant dentistry in dental hygiene and therapy schools in the UK and Ireland.
Jann Siew Chin, Liam D Addy, Jeremy Rees, Matthew Locke

Br Dent J· May 2019

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The Efficacy of Plasma Rich in Growth Factors for the Treatment of Alveolar Osteitis: A Randomized Controlled Trial.
Elizabeth M King, Tanya L Cerajewska, Matthew Locke, Nicholas C A Claydon, Maria Davies

J Oral Maxillofac Surg· June 2018

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Oral mucosal progenitor cell clones resist in vitro myogenic differentiation.
Matthew Locke, Lindsay C Davies, Phil Stephens

Arch Oral Biol· October 2016

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Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.
Matthew Locke, Essam Ghazaly, Marta O Freitas, Mikaella Mitsinga, Laura Lattanzio

Cell Rep· August 2016

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Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
Guido Moll, Jessica J Alm, Lindsay C Davies, Lena von Bahr, Nina Heldring, Matthew Locke

Stem Cells· September 2014

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Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation.
Matthew Locke, Julia I Toth, Matthew D Petroski

Biochem J· April 2014

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