Publications by authors named "Matthew Mangan"

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Topical application of a CCL22-binding aptamer suppresses contact allergy.
Anna Jonczyk, Marlene Gottschalk, Matthew S J Mangan, Yasmin Majlesain, Manja W Thiem

Mol Ther Nucleic Acids· September 2024

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Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation.
Wei Wang, Alesja Dernst, Bianca Martin, Lucia Lorenzi, Maria Cadefau-Fabregat, Matthew S J Mangan

Cell Rep· September 2024

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Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.
Jean-Philippe Auger, Max Zimmermann, Maria Faas, Ulrich Stifel, David Chambers, Matthew S J Mangan

Nature· May 2024

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Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.
Maximilian Nickenig, Matthew S J Mangan, Hye Eun Lee, Konstantinos Symeonidis, Antonia Henne

J Immunol· January 2024

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Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation.
Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Kateryna Shkarina, Matilde B Vasconcelos

Methods Mol Biol· August 2023

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Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation.
Marta Lovotti, Matthew S J Mangan, Róisín M McManus, Kateryna Shkarina, Matilde B Vasconcelos

Methods Mol Biol· August 2023

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Mitochondrial damage activates the NLRP10 inflammasome.
Tomasz Próchnicki, Matilde B Vasconcelos, Kim S Robinson, Matthew S J Mangan, Dennis De Graaf

Nat Immunol· April 2023

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How location and cellular signaling combine to activate the NLRP3 inflammasome.
Anil Akbal, Alesja Dernst, Marta Lovotti, Matthew S J Mangan, Róisín M McManus

Cell Mol Immunol· November 2022

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Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.
Matthew S J Mangan, Friederike Gorki, Karoline Krause, Alexander Heinz, Anne Pankow

PLoS Biol· November 2022

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Impairment of lysosomal function by Clostridioides difficile TcdB.
Carmen Klepka, Moritz Sandmann, Helma Tatge, Matthew Mangan, Annabel Arens

Mol Microbiol· February 2022

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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Marco Orecchioni, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Matthew Mangan

Science· January 2022

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BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Matthew Mangan

J Exp Med· November 2021

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1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.
Mario A Lauterbach, Victor Saavedra, Matthew S J Mangan, Anke Penno, Christoph Thiele

Autophagy· August 2021

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Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.
Joel Selkrig, Nan Li, Annika Hausmann, Matthew S J Mangan, Matylda Zietek

Nat Microbiol· September 2020

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Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.
Mario A Lauterbach, Jasmin E Hanke, Magdalini Serefidou, Matthew S J Mangan, Carl-Christian Kolbe

Immunity· December 2019

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Ecological modeling over seven years to describe the number of host-seeking Amblyomma americanum in each life stage in northeast Missouri.
Matthew J Mangan, Stephanie A Foré, Hyun-Joo Kim

J Vector Ecol· December 2018

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Targeting the NLRP3 inflammasome in inflammatory diseases.
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick

Nat Rev Drug Discov· September 2018

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Targeting the NLRP3 inflammasome in inflammatory diseases.
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick

Nat Rev Drug Discov· August 2018

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TAK1ng control: TAK1 restrains NLRP3 activation.
Matthew Stephen Mangan, Eicke Latz

J Exp Med· April 2018

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A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.
Matthew S Mangan, Carolina R Melo-Silva, Jennii Luu, Catherina H Bird, Aulikki Koskinen

Immunol Cell Biol· November 2017

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Michael J Primiano, Bruce A Lefker, Michael R Bowman, Andrea G Bree, Cedric Hubeau, Matthew Mangan

J Immunol· September 2016

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Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation.
Tomasz Próchnicki, Matthew S Mangan, Eicke Latz

F1000Res· August 2016

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Crystal Formation in Inflammation.
Bernardo S Franklin, Matthew S Mangan, Eicke Latz

Annu Rev Immunol· May 2016

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A Novel Serpin Regulatory Mechanism: SerpinB9 IS REVERSIBLY INHIBITED BY VICINAL DISULFIDE BOND FORMATION IN THE REACTIVE CENTER LOOP.
Matthew S J Mangan, Catherina H Bird, Dion Kaiserman, Anthony Y Matthews, Corinne Hitchen

J Biol Chem· February 2016

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Bernardo S Franklin, Lukas Bossaller, Dominic De Nardo, Jacqueline M Ratter, Andrea Stutz, Matthew S Mangan

Nat Immunol· August 2014

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