Publications by authors named "Mayne Christopher"

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Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2).
Young Chen, Brandon Whitefield, Erin Nevius, Mark Hill, Joselyn DelRosario, Christopher Glenn Mayne

J Med Chem· December 2023

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Assembly and Analysis of Cell-Scale Membrane Envelopes.
Josh V Vermaas, Christopher G Mayne, Eric Shinn, Emad Tajkhorshid

J Chem Inf Model· February 2022

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Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer.
Christopher G Mayne, Weiyi Toy, Kathryn E Carlson, Trusha Bhatt, Sean W Fanning

Mol Cancer Res· September 2021

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A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.
Yin Li, Laurel A Coons, René Houtman, Kathryn E Carlson, Teresa A Martin, Christopher G Mayne

Sci Signal· September 2020

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Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Mary E Matyskiela, Thomas Clayton, Xinde Zheng, Christopher Mayne, Eileen Tran

Nat Struct Mol Biol· April 2020

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The Role of Micronutrients in Graft-VS.-Host Disease: Immunomodulatory Effects of Vitamins A and D.
Xiao Chen, Christopher G Mayne

Front Immunol· October 2019

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Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain.
Abhishek Sharma, Weiyi Toy, Valeria Sanabria Guillen, Naina Sharma, Jian Min, Christopher G Mayne

ACS Chem Biol· December 2018

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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi

Elife· November 2018

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Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.
John A Katzenellenbogen, Christopher G Mayne, Benita S Katzenellenbogen, Geoffrey L Greene, Sarat Chandarlapaty

Nat Rev Cancer· October 2018

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A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.
Jonathan C Jeschke, Christopher G Mayne, Jennifer Ziegelbauer, Christopher L DeCiantis, Selina Singh

Mucosal Immunol· July 2018

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Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.
John A Katzenellenbogen, Christopher G Mayne, Benita S Katzenellenbogen, Geoffrey L Greene, Sarat Chandarlapaty

Nat Rev Cancer· June 2018

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A "cross-stitched" peptide with improved helicity and proteolytic stability.
Thomas E Speltz, Christopher G Mayne, Sean W Fanning, Zamia Siddiqui, Emad Tajkhorshid

Org Biomol Chem· May 2018

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Surgery for recurrent stress urinary incontinence: the views of surgeons and women.
Douglas G Tincello, Natalie Armstrong, Paul Hilton, Brian Buckley, Christopher Mayne

Int Urogynecol J· January 2018

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Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.
Jian Min, Valeria Sanabria Guillen, Abhishek Sharma, Yuechao Zhao, Yvonne Ziegler, Christopher G Mayne

J Med Chem· July 2017

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A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the ion channel.
Mark J Arcario, Christopher G Mayne, Emad Tajkhorshid

J Biol Chem· June 2017

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Comparison of the effectiveness of repeated injections of onabotulinum toxin A for refractory idiopathic detrusor overactivity: analysis of an open label extension of a randomized trial (the RELAX study).
Rhiannon K Owen, Keith R Abrams, Christopher Mayne, Mark Slack, Douglas G Tincello

Neurourol Urodyn· April 2017

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Patient factors associated with onabotulinum toxin A treatment outcome in women with detrusor overactivity.
Rhiannon K Owen, Keith R Abrams, Christopher Mayne, Mark Slack, Douglas G Tincello

Neurourol Urodyn· February 2017

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The cellular membrane as a mediator for small molecule interaction with membrane proteins.
Christopher G Mayne, Mark J Arcario, Paween Mahinthichaichan, Javier L Baylon, Josh V Vermaas

Biochim Biophys Acta· October 2016

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Adaptive Multilevel Splitting Method for Molecular Dynamics Calculation of Benzamidine-Trypsin Dissociation Time.
Ivan Teo, Christopher G Mayne, Klaus Schulten, Tony Lelièvre

J Chem Theory Comput· June 2016

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All-Atom Molecular Dynamics of Virus Capsids as Drug Targets.
Juan R Perilla, Jodi A Hadden, Boon Chong Goh, Christopher G Mayne, Klaus Schulten

J Phys Chem Lett· May 2016

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Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.
Zeynep Madak-Erdogan, Sung Hoon Kim, Ping Gong, Yiru C Zhao, Hui Zhang, Christopher G Mayne

Sci Signal· May 2016

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Flexibility Coexists with Shape-Persistence in Cyanostar Macrocycles.
Yun Liu, Abhishek Singharoy, Christopher G Mayne, Arkajyoti Sengupta, Krishnan Raghavachari

J Am Chem Soc· April 2016

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Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions.
Parisa Hosseinzadeh, Evan N Mirts, Thomas D Pfister, Yi-Gui Gao, Christopher Mayne

Biochemistry· March 2016

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Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
Thomas E Speltz, Sean W Fanning, Christopher G Mayne, Colin Fowler, Emad Tajkhorshid

Angew Chem Int Ed Engl· March 2016

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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Sean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, Kathryn E Carlson, Teresa A Martin

Elife· February 2016

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