Publications by authors named "Mechthild Jonas"

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Brentuximab Vedotin-Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity.
Ryan A Heiser, Anthony T Cao, Weiping Zeng, Michelle Ulrich, Patrick Younan, Mechthild Jonas

Mol Cancer Ther· January 2024

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SGN-B6A: A New Vedotin Antibody-Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications.
Robert P Lyon, Mechthild Jonas, Christopher Frantz, Esther S Trueblood, Roma Yumul

Mol Cancer Ther· December 2023

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An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics.
David W Meyer, Lauren B Bou, Sara Shum, Mechthild Jonas, Martha E Anderson

Mol Pharm· March 2020

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Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia.
Fu Li, May Kung Sutherland, Changpu Yu, Roland B Walter, Lori Westendorf, Mechthild Jonas

Mol Cancer Ther· February 2018

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Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody-Drug Conjugates.
Fu Li, Michelle Ulrich, Mechthild Jonas, Ivan J Stone, Germein Linares

Mol Cancer Ther· July 2017

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Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
Fu Li, Kim K Emmerton, Mechthild Jonas, Xinqun Zhang, Jamie B Miyamoto

Cancer Res· May 2016

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Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index.
Robert P Lyon, Tim D Bovee, Svetlana O Doronina, Patrick J Burke, Joshua H Hunter, Mechthild Jonas

Nat Biotechnol· July 2015

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Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia.
May Kung Sutherland, Changpu Yu, Timothy S Lewis, Jamie B Miyamoto, Carol A Morris-Tilden, Mechthild Jonas

MAbs· April 2010

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A novel mutation in CD83 results in the development of a unique population of CD4+ T cells.
Leon F García-Martínez, Mark W Appleby, Karen Staehling-Hampton, Dawn M Andrews, Yuching Chen, Mechthild Jonas

J Immunol· September 2004

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Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils.
Chien-Ying Liu, Akihiro Takemasa, W Conrad Liles, Richard B Goodman, Mechthild Jonas

Blood· January 2003

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A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model.
William R Henderson, Li-Ou Tang, Shi-Jye Chu, Shih-Ming Tsao, Gertrude K S Chiang, Mechthild Jonas

Am J Respir Crit Care Med· January 2002

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