Publications by authors named "Mehlika D Altıntop"

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Design, synthesis, in vitro and in silico evaluation of thiazole-hydrazone hybrids as potent and safe α-glucosidase inhibitors.
Ali Ergüç, Emre Kadir Ayan, Muhammed Tilahun Muhammed, Ahmet Özdemir, Mehlika Dilek Altıntop

Bioorg Chem· December 2025

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Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy.
Mehlika Dilek Altıntop, İpek Ertorun, Gülşen Akalın Çiftçi, Ahmet Özdemir

Eur J Med Chem· October 2024

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Design, Synthesis, and Evaluation of New Pyrazolines As Small Molecule Inhibitors of Acetylcholinesterase.
Mehlika Dilek Altıntop, Begüm Nurpelin Sağlık Özkan, Ahmet Özdemir

ACS Omega· July 2024

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Design, Synthesis, and Evaluation of a New Series of Indole-Chalcone Hybrids as Analgesic and Anti-Inflammatory Agents.
Iman Baramaki, Mehlika Dilek Altıntop, Rana Arslan, Feyza Alyu Altınok, Ahmet Özdemir

ACS Omega· March 2024

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Design, Synthesis, and Evaluation of a New Series of 2-Pyrazolines as Potential Antileukemic Agents.
Mehlika Dilek Altıntop, Zerrin Cantürk, Ahmet Özdemir

ACS Omega· November 2023

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Design, Synthesis, and Evaluation of a New Series of Hydrazones as Small-Molecule Akt Inhibitors for NSCLC Therapy.
Burak Erdönmez, Mehlika Dilek Altıntop, Gülşen Akalın Çiftçi, Ahmet Özdemir, Abdulilah Ece

ACS Omega· June 2023

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A new series of thiazole-hydrazone hybrids for Akt-targeted therapy of non-small cell lung cancer.
Turana Orujova, Abdulilah Ece, Gülşen Akalın Çiftçi, Ahmet Özdemir, Mehlika D Altıntop

Drug Dev Res· April 2023

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A new series of hydrazones as small-molecule aldose reductase inhibitors.
Mehlika D Altıntop, Yeliz Demir, Cüneyt Türkeş, Remzi B Öztürk, Zerrin Cantürk

Arch Pharm (Weinheim)· April 2023

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Discovery of Small Molecule COX-1 and Akt Inhibitors as Anti-NSCLC Agents Endowed with Anti-Inflammatory Action.
Mehlika Dilek Altıntop, Gülşen Akalın Çiftçi, Nalan Yılmaz Savaş, İpek Ertorun, Betül Can

Int J Mol Sci· January 2023

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Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and prostate cancer.
Mehlika Dilek Altıntop, Ahmet Özdemir, Halide Edip Temel, Bahar Demir Cevizlidere, Belgin Sever

Eur J Med Chem· December 2022

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A new series of thiosemicarbazone-based anti-inflammatory agents exerting their action through cyclooxygenase inhibition.
Mehlika D Altıntop, Belgin Sever, Gülşen Akalın Çiftçi, İpek Ertorun, Özkan Alataş

Arch Pharm (Weinheim)· September 2022

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A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-Small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into Their Anticancer Potencies.
Belgin Sever, Mehlika Dilek Altıntop, Gülşen Akalın Çiftçi, Ahmet Özdemir

Med Chem· January 2022

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A New Series of Indeno[1,2-]pyrazoles as EGFR TK Inhibitors for NSCLC Therapy.
Ahmet Özdemir, Halilibrahim Ciftci, Belgin Sever, Hiroshi Tateishi, Masami Otsuka, Mehlika Dilek Altıntop

Molecules· January 2022

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A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors.
Ebru Zeytün, Mehlika D Altıntop, Belgin Sever, Ahmet Özdemir, Doha E Ellakwa

Anticancer Agents Med Chem· December 2021

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Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds.
Belgin Sever, Cüneyt Türkeş, Mehlika D Altıntop, Yeliz Demir, Gülşen Akalın Çiftçi

Arch Pharm (Weinheim)· December 2021

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EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.
Halil I Ciftci, Mohamed O Radwan, Belgin Sever, Ahmed K Hamdy, Safiye Emirdağ

Int J Mol Sci· October 2021

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Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines.
Belgin Sever, Mehlika Dilek Altıntop, Yeliz Demir, Nalan Yılmaz, Gülşen Akalın Çiftçi

Chem Biol Interact· August 2021

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A new series of benzoxazole-based SIRT1 modulators for targeted therapy of non-small-cell lung cancer.
Belgin Sever, Gülşen Akalın Çiftçi, Mehlika Dilek Altıntop

Arch Pharm (Weinheim)· January 2021

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Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors.
Belgin Sever, Cüneyt Türkeş, Mehlika Dilek Altıntop, Yeliz Demir, Şükrü Beydemir

Int J Biol Macromol· November 2020

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In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors.
Belgin Sever, Mehlika Dilek Altıntop, Ahmet Özdemir, Gülşen Akalın Çiftçi, Doha E Ellakwa

Molecules· November 2020

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Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects.
Belgin Sever, Hasan Soybir, Şennur Görgülü, Zerrin Cantürk, Mehlika Dilek Altıntop

Molecules· October 2020

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Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds.
Belgin Sever, Mehlika Dilek Altıntop, Yeliz Demir, Gülşen Akalın Çiftçi, Şükrü Beydemir

Bioorg Chem· September 2020

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Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka

Eur J Med Chem· November 2019

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Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells.
Gülşen Akalin Çiftçi, Belgin Sever, Mehlika Dilek Altintop

Turk J Pharm Sci· June 2019

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Synthesis and Evaluation of a New Series of Thiazolyl-pyrazoline Derivatives as Cholinesterase Inhibitors.
Halide Edip Temel, Mehlika Dilek Altintop, Ahmet Özdemir

Turk J Pharm Sci· December 2018

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