Publications by authors named "Michael A Colman"

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Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia.
Ewan D Fowler, Salimata L Diakite, Ana M Gomez, Michael A Colman

J Mol Cell Cardiol Plus· September 2025

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High-resolution 3D visualization of human hearts with emphases on the cardiac conduction system components-a new platform for medical education, mix/virtual reality, computational simulation.
Weixuan Chen, Marcin Kuniewicz, Abimbola J Aminu, Irem Karaesmen, Neal Duong, Michael A Colman

Front Med (Lausanne)· February 2025

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RyR cooperativity and mobile buffers: functional clues to the resolution of the cardiac calcium wave problem?
Michael A Colman

J Physiol· December 2024

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Interactions between calcium-induced arrhythmia triggers and the electrophysiological-anatomical substrate underlying the induction of atrial fibrillation.
Michael A Colman, Marta Varela, Rob S MacLeod, Jules C Hancox, Oleg V Aslanidi

J Physiol· March 2024

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Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction.
Ever Espino-Gonzalez, Peter G Tickle, Raffaele Altara, Harrison Gallagher, Chew W Cheng, Michael A Colman

JACC Basic Transl Sci· February 2024

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Patchy fibrosis promotes trigger-substrate interactions that both generate and maintain atrial fibrillation.
Michael A Colman, Roshan Sharma, Oleg V Aslanidi, Jichao Zhao

Interface Focus· December 2023

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A simple approach for image-based modelling of the heart that enables robust simulation of highly heterogeneous electrical excitation.
Michael A Colman, Alan P Benson

Sci Rep· September 2023

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Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes.
Luke A Howlett, Harley Stevenson-Cocks, Michael A Colman, Matthew K Lancaster, Alan P Benson

Physiol Rep· July 2023

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On the importance of ryanodine receptor subunit cooperativity in the heart.
Xianwei Zhang, Michael A Colman

Biophys J· January 2023

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Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives.
Michael A Colman, Enrique Alvarez-Lacalle, Blas Echebarria, Daisuke Sato, Henry Sutanto

Front Physiol· March 2022

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Multi-scale approaches for the simulation of cardiac electrophysiology: II - Tissue-level structure and function.
Alan P Benson, Harley J Stevenson-Cocks, Dominic G Whittaker, Ed White, Michael A Colman

Methods· January 2021

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Multi-scale approaches for the simulation of cardiac electrophysiology: I - Sub-cellular and stochastic calcium dynamics from cell to organ.
Michael A Colman, Maxx Holmes, Dominic G Whittaker, Izzy Jayasinghe, Alan P Benson

Methods· January 2021

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The Multiple Mechanisms of Spatially Discordant Alternans in the Heart.
Michael A Colman

Biophys J· May 2020

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Investigation of the Role of Myocyte Orientations in Cardiac Arrhythmia Using Image-Based Models.
Dominic G Whittaker, Alan P Benson, Irvin Teh, Jürgen E Schneider, Michael A Colman

Biophys J· December 2019

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Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation.
Michael A Colman

PLoS Comput Biol· August 2019

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Dynamic clamping human and rabbit atrial calcium current: narrowing I window abolishes early afterdepolarizations.
Sarah Kettlewell, Priyanka Saxena, John Dempster, Michael A Colman, Rachel C Myles

J Physiol· July 2019

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Effects of Heart Rate and Ventricular Wall Thickness on Non-invasive Mapping: An Study.
Erick Andres Perez Alday, Dominic G Whittaker, Alan P Benson, Michael A Colman

Front Physiol· April 2019

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Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy.
Thomas M D Sheard, Miriam E Hurley, John Colyer, Ed White, Ruth Norman, Michael A Colman

ACS Nano· February 2019

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Human Atrial Arrhythmogenesis and Sinus Bradycardia in -Linked Short QT Syndrome: Insights From Computational Modelling.
Dominic G Whittaker, Michael A Colman, Haibo Ni, Jules C Hancox, Henggui Zhang

Front Physiol· October 2018

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Description of the Human Atrial Action Potential Derived From a Single, Congruent Data Source: Novel Computational Models for Integrated Experimental-Numerical Study of Atrial Arrhythmia Mechanisms.
Michael A Colman, Priyanka Saxena, Sarah Kettlewell, Antony J Workman

Front Physiol· September 2018

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Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator.
Michael A Colman, Erick A Perez Alday, Arun V Holden, Alan P Benson

Front Physiol· October 2017

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A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions.
Michael A Colman, Christian Pinali, Andrew W Trafford, Henggui Zhang, Ashraf Kitmitto

PLoS Comput Biol· August 2017

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In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.
Michael A Colman, Haibo Ni, Bo Liang, Nicole Schmitt, Henggui Zhang

PLoS Comput Biol· June 2017

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Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs: A computational study.
Erick A Perez Alday, Michael A Colman, Philip Langley, Henggui Zhang

PLoS Comput Biol· March 2017

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Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models.
Marta Varela, Michael A Colman, Jules C Hancox, Oleg V Aslanidi

PLoS Comput Biol· December 2016

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