Publications by authors named "Michael A Walker"

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Grape cultivars adapted to hotter, drier growing regions exhibit greater photosynthesis in hot conditions despite less drought-resistant leaves.
Gabriela Sinclair, Erin R Galarneau, Josh F Hnizdor, Andrew J McElrone, Michael Andrew Walker

Ann Bot· July 2024

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Preclinical characterization of ABI-H2158, an HBV core inhibitor with dual mechanisms of action.
Ran Yan, Dawei Cai, Yuhua Zong, Lida Guo, Yi Zhou, Michael A Walker

Antiviral Res· January 2023

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Haplotype-resolved powdery mildew resistance loci reveal the impact of heterozygous structural variation on NLR genes in Muscadinia rotundifolia.
Mélanie Massonnet, Amanda M Vondras, Noé Cochetel, Summaira Riaz, Dániel Pap, Michael Andrew Walker

G3 (Bethesda)· July 2022

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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
Kyle Parcella, Tao Wang, Kyle Eastman, Zhongxing Zhang, Zhiwei Yin, Michael A Walker

ACS Med Chem Lett· June 2022

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Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Manoj Patel, B Narasimhulu Naidu, Ira Dicker, Helen Higley, Zeyu Lin, Michael A Walker

Bioorg Med Chem· July 2020

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Guo Li, Nicholas A Meanwell, Mark R Krystal, David R Langley, B Narasimhulu Naidu, Michael A Walker

J Med Chem· March 2020

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Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Kevin M Peese, B Narasimhulu Naidu, Manoj Patel, Chen Li, David R Langley, Michael A Walker

Bioorg Med Chem Lett· February 2020

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5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
Kevin M Peese, Christopher W Allard, Timothy Connolly, Barry L Johnson, Chen Li, Michael A Walker

J Med Chem· February 2019

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Overexpression of 9--Epoxycarotenoid Dioxygenase Cisgene in Grapevine Increases Drought Tolerance and Results in Pleiotropic Effects.
Rongrong He, Yuan Zhuang, Yumeng Cai, Cecilia B Agüero, Shaoli Liu, Michael A Walker

Front Plant Sci· August 2018

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The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
B Narasimhulu Naidu, Michael A Walker, Margaret E Sorenson, Yasutsugu Ueda, John D Matiskella

Bioorg Med Chem Lett· July 2018

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Improvement in aqueous solubility achieved via small molecular changes.
Michael A Walker

Bioorg Med Chem Lett· December 2017

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Low-event-rate meta-analyses of clinical trials: implementing good practices.
Jonathan J Shuster, Michael A Walker

Stat Med· June 2016

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Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
B Narasimhulu Naidu, Margaret E Sorenson, Manoj Patel, Yasutsugu Ueda, Jacques Banville, Michael A Walker

Bioorg Med Chem Lett· February 2015

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Novel tactics for designing water-soluble molecules in drug discovery.
Michael A Walker

Expert Opin Drug Discov· December 2014

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Tandem ring-closing metathesis/transfer hydrogenation: practical chemoselective hydrogenation of alkenes.
Timothy Connolly, Zhongyu Wang, Michael A Walker, Ivar M McDonald, Kevin M Peese

Org Lett· September 2014

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Reproductive mode and fine-scale population genetic structure of grape phylloxera (Daktulosphaira vitifoliae) in a viticultural area in California.
Md Sajedul Islam, Tamara L Roush, Michael Andrew Walker, Jeffrey Granett, Hong Lin

BMC Genet· December 2013

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New first and second generation inhibitors of human immunodeficiency virus-1 integrase.
Annapurna Pendri, Nicholas A Meanwell, Kevin M Peese, Michael A Walker

Expert Opin Ther Pat· August 2011

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Focal skeletal muscle uptake of 99mTechnetium-hydroxymethylene diphosphonate following peroneal nerve blocks in horses.
John F Griffin, Benjamin D Young, Geoffrey T Fosgate, Michael A Walker, Jeffrey P Watkins

Vet Radiol Ultrasound· June 2010

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Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
Annapurna Pendri, Timothy L Troyer, Michael J Sofia, Michael A Walker, B Narasimhulu Naidu

J Comb Chem· March 2010

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New approaches for inhibiting HIV integrase: a journey beyond the active site.
Michael A Walker

Curr Opin Investig Drugs· February 2009

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The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.
David R Langley, Himadri K Samanta, Zeyu Lin, Michael A Walker, Mark R Krystal

Biochemistry· December 2008

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Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.
Ira B Dicker, Brian Terry, Zeyu Lin, Zhufang Li, Sagarika Bollini, Michael A Walker

J Biol Chem· August 2008

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Treatment of autism spectrum disorders: neurotransmitter signaling pathways involved in motivation and reward as therapeutic targets.
Michael A Walker

Expert Opin Ther Targets· August 2008

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Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
Ira B Dicker, Himadri K Samanta, Zhufang Li, Yang Hong, Yuan Tian, Michael A Walker

J Biol Chem· October 2007

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Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992-2004).
Jonathan M Levine, Emma Adam, Robert J MacKay, Michael A Walker, Jeremy D Frederick

J Vet Intern Med· September 2007

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