Publications by authors named "Ira B Dicker"

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Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Kyle Parcella, Manoj Patel, Yong Tu, Kyle Eastman, Kevin Peese, Ira B Dicker

Bioorg Med Chem· August 2022

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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
Kyle Parcella, Tao Wang, Kyle Eastman, Zhongxing Zhang, Zhiwei Yin, Ira B Dicker

ACS Med Chem Lett· June 2022

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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Jacob J Swidorski, Susan Jenkins, Umesh Hanumegowda, Dawn D Parker, Brett R Beno, Ira B Dicker

Bioorg Med Chem Lett· March 2021

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Guo Li, Nicholas A Meanwell, Mark R Krystal, David R Langley, B Narasimhulu Naidu, Ira B Dicker

J Med Chem· March 2020

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Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Kevin M Peese, B Narasimhulu Naidu, Manoj Patel, Chen Li, David R Langley, Ira B Dicker

Bioorg Med Chem Lett· February 2020

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Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial.
Javier Morales-Ramirez, Johannes R Bogner, Jean-Michel Molina, Johan Lombaard, Ira B Dicker

PLoS One· March 2019

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Second Generation Inhibitors of HIV-1 Maturation.
Alicia Regueiro-Ren, Ira B Dicker, Umesh Hanumegowda, Nicholas A Meanwell

ACS Med Chem Lett· March 2019

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
Alicia Regueiro-Ren, Jacob J Swidorski, Zheng Liu, Yan Chen, Ny Sin, Ira B Dicker

J Med Chem· August 2018

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The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
B Narasimhulu Naidu, Michael A Walker, Margaret E Sorenson, Yasutsugu Ueda, John D Matiskella, Ira B Dicker

Bioorg Med Chem Lett· July 2018

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Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).
Carey Hwang, Dirk Schürmann, Christian Sobotha, Marta Boffito, Heather Sevinsky, Ira B Dicker

Clin Infect Dis· August 2017

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Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.
Zeyu Lin, Joseph Cantone, Hao Lu, Beata Nowicka-Sans, Tricia Protack, Ira B Dicker

PLoS Pathog· November 2016

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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Zhufang Li, Sharon Zhang, Ira B Dicker

Antimicrob Agents Chemother· July 2016

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Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
Alicia Regueiro-Ren, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Ira B Dicker

ACS Med Chem Lett· June 2016

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C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Zheng Liu, Jacob J Swidorski, Beata Nowicka-Sans, Brian Terry, Tricia Protack, Ira B Dicker

Bioorg Med Chem· April 2016

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Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Jacob J Swidorski, Zheng Liu, Sing-Yuen Sit, Jie Chen, Yan Chen, Ira B Dicker

Bioorg Med Chem Lett· April 2016

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Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
B Narasimhulu Naidu, Margaret E Sorenson, Manoj Patel, Yasutsugu Ueda, Jacques Banville, Ira B Dicker

Bioorg Med Chem Lett· February 2015

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Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.
Tao Wang, Zhiwei Yin, Zhongxing Zhang, John A Bender, Zhong Yang, Ira B Dicker

J Med Chem· December 2009

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The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.
David R Langley, Himadri K Samanta, Zeyu Lin, Michael A Walker, Mark R Krystal, Ira B Dicker

Biochemistry· December 2008

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Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.
Ira B Dicker, Brian Terry, Zeyu Lin, Zhufang Li, Sagarika Bollini

J Biol Chem· August 2008

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Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
Ira B Dicker, Himadri K Samanta, Zhufang Li, Yang Hong, Yuan Tian

J Biol Chem· October 2007

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PolC-type polymerase III of Streptococcus pyogenes and its use in screening for chemical inhibitors.
Fude Yang, Ira B Dicker, Michael G Kurilla, David L Pompliano

Anal Biochem· May 2002

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Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated.
Jeffrey T Billheimer, Ira B Dicker, Richard Wynn, Jodi D Bradley, Debra A Cromley

Blood· May 2002

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Homogenous assays for Escherichia coli DnaB-stimulated DnaG primase and DnaB helicase and their use in screening for chemical inhibitors.
Yi Zhang, Fude Yang, Yeh-Chih Kao, Michael G Kurilla, David L Pompliano, Ira B Dicker

Anal Biochem· May 2002

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