Publications by authors named "Michael D Bright"

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Discovery of an Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
Alice C Harnden, Owen A Davis, Gary M Box, Angela Hayes, Louise D Johnson, Michael D Bright

J Med Chem· April 2023

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Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 .
Rosemary Huckvale, Alice C Harnden, Kwai-Ming J Cheung, Olivier A Pierrat, Rachel Talbot, Michael D Bright

J Med Chem· June 2022

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Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.
Owen A Davis, Kwai-Ming J Cheung, Alfie Brennan, Matthew G Lloyd, Matthew J Rodrigues, Michael D Bright

J Med Chem· June 2022

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Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.
Matthew G Lloyd, Rosemary Huckvale, Kwai-Ming J Cheung, Matthew J Rodrigues, Gavin W Collie, Michael D Bright

J Med Chem· December 2021

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Achieving Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
Benjamin R Bellenie, Kwai-Ming J Cheung, Ana Varela, Olivier A Pierrat, Gavin W Collie, Michael D Bright

J Med Chem· April 2020

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HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.
Jacqueline H L Fok, Somaieh Hedayat, Lei Zhang, Lauren I Aronson, Fabio Mirabella, Michael D Bright

Clin Cancer Res· May 2018

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Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling.
Michael D Bright, Paul A Clarke, Paul Workman, Faith E Davies

Cell Signal· April 2018

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An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration.
Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D Bright

BMC Biol· March 2018

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Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress.
Michael D Bright, Daniel N Itzhak, Christopher P Wardell, Gareth J Morgan, Faith E Davies

Mol Cell Biol· June 2015

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The motor protein myosin 1G functions in FcγR-mediated phagocytosis.
Anna E Dart, Sylvain Tollis, Michael D Bright, Gad Frankel, Robert G Endres

J Cell Sci· December 2012

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PAK4 phosphorylates myosin regulatory light chain and contributes to Fcγ receptor-mediated phagocytosis.
Michael D Bright, Gad Frankel

Int J Biochem Cell Biol· December 2011

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Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.
Alexander R C Wong, Jaclyn S Pearson, Michael D Bright, Diana Munera, Keith S Robinson

Mol Microbiol· June 2011

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PAK1 and PAK2 have different roles in HGF-induced morphological responses.
Michael D Bright, Andrew P Garner, Anne J Ridley

Cell Signal· December 2009

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