Publications by authors named "Michael D Onken"

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Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein-driven calcium oscillations.
Michael D Onken, Carol M Makepeace, Kevin M Kaltenbronn, McKenzie Demourelle-Washington, Kisha D Piggott

J Biol Chem· September 2025

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Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses.
Michael D Onken, Petra Erdmann-Gilmore, Qiang Zhang, Kisan Thapa, Emily King

Mol Cell Proteomics· November 2023

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Septin and actin contributions to endothelial cell-cell junctions and monolayer integrity.
Joanna Kim, Olivia L Mooren, Michael D Onken, John A Cooper

Cytoskeleton (Hoboken)· October 2022

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Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma.
Michael D Onken, Sarah E Noda, Kevin M Kaltenbronn, Cheryl Frankfater, Carol M Makepeace

J Biol Chem· January 2022

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Targeting primary and metastatic uveal melanoma with a G protein inhibitor.
Michael D Onken, Carol M Makepeace, Kevin M Kaltenbronn, Joelle Choi, Leonel Hernandez-Aya

J Biol Chem· September 2021

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Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium.
Michael D Onken, Kendall J Blumer, John A Cooper

Mol Biol Cell· March 2021

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Chloroquine Sensitizes -mutated Melanoma to MEK1/2 Inhibition.
Amanda Truong, Jae Hyuk Yoo, Michael T Scherzer, John Michael S Sanchez, Kali J Dale, Michael D Onken

Clin Cancer Res· December 2020

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The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration.
Lisa L Drewry, Nathaniel G Jones, Quiling Wang, Michael D Onken, Mark J Miller

Nat Microbiol· November 2019

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Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma.
Matthew Yen, Zongtai Qi, Xuhua Chen, John A Cooper, Robi D Mitra, Michael D Onken

BMC Med Genomics· November 2018

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Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells.
Michael D Onken, Carol M Makepeace, Kevin M Kaltenbronn, Stanley M Kanai, Tyson D Todd

Sci Signal· September 2018

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Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate.
Phillip J Stewart-Hutchinson, Taylor P Szasz, Emily R Jaeger, Michael D Onken, John A Cooper

J Leukoc Biol· September 2017

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Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.
Felipe H Santiago-Tirado, Michael D Onken, John A Cooper, Robyn S Klein, Tamara L Doering

mBio· January 2017

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L-Plastin promotes podosome longevity and supports macrophage motility.
Julie Y Zhou, Taylor P Szasz, Phillip J Stewart-Hutchinson, Janardan Sivapalan, Elizabeth M Todd, Michael D Onken

Mol Immunol· October 2016

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Uveal melanoma cells utilize a novel route for transendothelial migration.
Michael D Onken, Jinmei Li, John A Cooper

PLoS One· May 2016

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Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Daniel W Vermeer, Joseph D Coppock, Erliang Zeng, Kimberly M Lee, William C Spanos, Michael D Onken

Oncotarget· April 2016

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Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer.
Varun Chalivendra, Krishna Latha Kanchi, Michael D Onken, Ashley E Winkler, Elaine Mardis

Genom Data· March 2015

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Endothelial monolayers and transendothelial migration depend on mechanical properties of the substrate.
Michael D Onken, Olivia L Mooren, Suranjana Mukherjee, Stefanie T Shahan, Jinmei Li

Cytoskeleton (Hoboken)· December 2014

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A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.
Michael D Onken, Ashley E Winkler, Krishna-Latha Kanchi, Varun Chalivendra, Jonathan H Law

Clin Cancer Res· June 2014

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BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma.
Katie A Matatall, Olga A Agapova, Michael D Onken, Lori A Worley, Anne M Bowcock

BMC Cancer· August 2013

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Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.
Abdoulaye Sene, Aslam A Khan, Douglas Cox, Rei E I Nakamura, Andrea Santeford, Michael D Onken

Cell Metab· April 2013

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Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.
J William Harbour, Elisha D O Roberson, Hima Anbunathan, Michael D Onken, Lori A Worley

Nat Genet· February 2013

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Gene expressing profiling of iris melanomas.
J William Harbour, David Wilson, Paul T Finger, Lori A Worley, Michael D Onken

Ophthalmology· January 2013

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Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.
Michael D Onken, Lori A Worley, Devron H Char, James J Augsburger, Zelia M Correa

Ophthalmology· August 2012

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Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
Solange Landreville, Olga A Agapova, Katie A Matatall, Zachary T Kneass, Michael D Onken

Clin Cancer Res· January 2012

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Frequent mutation of BAP1 in metastasizing uveal melanomas.
J William Harbour, Michael D Onken, Elisha D O Roberson, Shenghui Duan, Li Cao

Science· December 2010

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